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MIRAGE

bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE

Summary

Gene Symbol

hldE

Organism

Actinobacillus pleuropneumoniae

External Links

NCBI Gene: 48598568
KEGG Gene ID: [""]
PubChem: 48598568

Annotation

Keyword

ATP-binding
Carbohydrate metabolism
Kinase
Lipopolysaccharide biosynthesis
Multifunctional enzyme
Nucleotidyltransferase
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q8GLU7
A0A9Q4H5I1
A0ABM6X2M8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
lipopolysaccharide core region biosynthetic process	IEA
ADP-L-glycero-beta-D-manno-heptose biosynthetic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

ADP-L-glycero-beta-D-manno-heptose biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

ADP-L-glycero-beta-D-manno-heptose biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

ADP-L-glycero-beta-D-manno-heptose biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

ADP-L-glycero-beta-D-manno-heptose biosynthetic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

ADP-L-glycero-beta-D-manno-heptose biosynthetic process

biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

lipopolysaccharide core region biosynthetic process

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

ADP-L-glycero-beta-D-manno-heptose biosynthetic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

ADP-L-glycero-beta-D-manno-heptose biosynthetic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

ADP-L-glycero-beta-D-manno-heptose biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process [inference]

lipopolysaccharide core region biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

lipopolysaccharide core region biosynthetic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

ADP-L-glycero-beta-D-manno-heptose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

ADP-L-glycero-beta-D-manno-heptose biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

ADP-L-glycero-beta-D-manno-heptose biosynthetic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

ADP-L-glycero-beta-D-manno-heptose biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

ADP-L-glycero-beta-D-manno-heptose biosynthetic process

carbohydrate derivative metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

ADP-L-glycero-beta-D-manno-heptose biosynthetic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

ADP-L-glycero-beta-D-manno-heptose biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
cytosol	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

Displaying **all 5** entries
GO Term	Evidence Code	PMID
ATP binding	IEA
kinase activity	IEA
phosphotransferase activity, alcohol group as acceptor	IEA
heptose 7-phosphate kinase activity	IEA
heptose-1-phosphate adenylyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity

carbohydrate kinase activity [inference]

heptose 7-phosphate kinase activity

phosphotransferase activity, alcohol group as acceptor

nucleotidyltransferase activity [inference]

adenylyltransferase activity [inference]

heptose-1-phosphate adenylyltransferase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026