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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

solute carrier family 11 member 2

Summary

Gene Symbol

SLC11A2

Organism

Homo sapiens (human)

External Links

NCBI Gene

4891

KEGG Gene ID

PubChem

4891

Alliance of Genome Resources

HGNC:10908

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disease variant
Endosome
Glycoprotein
Golgi apparatus
Iron transport
Lysosome
Mitochondrion outer membrane
Phosphoprotein
Proteomics identification
Reference proteome
Symport
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
F8W1P7
A0A0X8GKR4
P49281	Divalent cation transporter 1 Divalent metal transporter 1 Solute carrier family 11 member 2

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
response to hypoxia	IEP
detection of oxygen	IEP
heme biosynthetic process
cobalt ion transport	IDA
cobalt ion transport	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

pigment metabolic process [inference]

heme metabolic process [inference]

heme biosynthetic process

pigment biosynthetic process [inference]

heme biosynthetic process

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

behavior [inference]

learning or memory

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

iron import into cell

intracellular manganese ion homeostasis

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

iron import into cell

intracellular manganese ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

iron import into cell

intracellular manganese ion homeostasis

manganese ion homeostasis [inference]

intracellular manganese ion homeostasis

multicellular organismal-level iron ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

iron import into cell

intracellular manganese ion homeostasis

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis

iron import into cell

manganese ion homeostasis [inference]

intracellular manganese ion homeostasis

multicellular organismal-level iron ion homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to abiotic stimulus [inference]

response to oxygen levels [inference]

detection of oxygen

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

response to metal ion [inference]

response to iron ion

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of oxygen

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport

transition metal ion transport [inference]

cobalt ion transport

copper ion transport

copper ion transmembrane transport

iron ion transport

manganese ion transport

manganese ion transmembrane transport

zinc ion transport [inference]

zinc ion transmembrane transport

nickel cation transport

nickel cation transmembrane transport

vanadium ion transport

cadmium ion transport [inference]

cadmium ion transmembrane transport

lead ion transport

monoatomic cation transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

establishment of localization in cell [inference]

iron import into cell

Displaying entries **1 - 5** of 48 in total

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GO Term	Evidence Code	PMID
nucleus	IDA
cytoplasm	IDA
mitochondrion	IDA
mitochondrion	HTP
mitochondrial outer membrane	EXP

GO Hierarchy

cellular component

protein-containing complex [inference]

paraferritin complex

cellular anatomical structure [inference]

plasma membrane

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

organelle outer membrane [inference]

mitochondrial outer membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

extracellular vesicle

intracellular membrane-bounded organelle [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
copper ion transmembrane transporter activity	IDA
iron ion transmembrane transporter activity	TAS
iron ion transmembrane transporter activity	IDA
iron ion transmembrane transporter activity	IEA
manganese ion transmembrane transporter activity	IDA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

solute:proton symporter activity

solute:monoatomic cation symporter activity [inference]

solute:proton symporter activity

metal ion transmembrane transporter activity

transition metal ion transmembrane transporter activity

copper ion transmembrane transporter activity

iron ion transmembrane transporter activity

ferrous iron transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:proton symporter activity

chromium ion transmembrane transporter activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

cadmium ion binding

protein-containing complex binding [inference]

retromer complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transporter

Functional Category

K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
cadmium ion transmembrane transporter activity
manganese ion transmembrane transporter activity
metal ion transmembrane transporter activity

Displaying 1 entry
InterPro
NRAMP family

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:11759	hypochromic anemia	Alliance of Genome Resources
DOID:332	amyotrophic lateral sclerosis	Alliance of Genome Resources
DOID:2355	anemia	Alliance of Genome Resources

Ortholog

Displaying **all 7** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	18174	MGI:1345279
Rattus norvegicus	25715	RGD:3684
Caenorhabditis elegans	180939	WB:WBGene00004876
Caenorhabditis elegans	191766	WB:WBGene00004877
Caenorhabditis elegans	177044	WB:WBGene00004878
Drosophila melanogaster	42490	FB:FBgn0011672
Saccharomyces cerevisiae S288C	850721	SGD:S000004024

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026