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Serpin 42Dd

Summary

Gene Symbol

Spn42Dd

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

49808

KEGG Gene ID

PubChem

49808

Alliance of Genome Resources

FB:FBgn0028988

Annotation

Keyword

Glycoprotein
Immunity
Reference proteome
Secreted
Serine protease inhibitor
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q7YTY6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
immune system process
negative regulation of antimicrobial peptide production	IMP
insemination	HEP
negative regulation of proteolysis	ISM
negative regulation of Toll receptor ligand protein activation cascade	IDA

GO Hierarchy

biological process

immune system process

reproductive process [inference]

multi-organism reproductive process [inference]

insemination

multicellular organismal reproductive process [inference]

insemination

multicellular organismal process [inference]

multi-multicellular organism process [inference]

insemination

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

regulation of production of molecular mediator of immune response [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

regulation of antifungal innate immune response [inference]

negative regulation of antifungal innate immune response

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

negative regulation of defense response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

negative regulation of response to external stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of response to biotic stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

regulation of antifungal innate immune response [inference]

negative regulation of antifungal innate immune response

regulation of defense response to fungus [inference]

regulation of antifungal innate immune response [inference]

negative regulation of antifungal innate immune response

regulation of response to external stimulus [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of response to external stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

regulation of antifungal innate immune response [inference]

negative regulation of antifungal innate immune response

regulation of defense response to fungus [inference]

regulation of antifungal innate immune response [inference]

negative regulation of antifungal innate immune response

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

negative regulation of defense response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

negative regulation of response to external stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

regulation of antifungal innate immune response [inference]

negative regulation of antifungal innate immune response

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of antifungal innate immune response

regulation of antifungal innate immune response [inference]

negative regulation of antifungal innate immune response

regulation of defense response to fungus [inference]

regulation of antifungal innate immune response [inference]

negative regulation of antifungal innate immune response

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein maturation [inference]

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

regulation of protein activation cascade [inference]

regulation of Toll receptor ligand protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of protein maturation [inference]

negative regulation of protein activation cascade [inference]

negative regulation of Toll receptor ligand protein activation cascade

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region	IBA
extracellular region	IEA
extracellular region	HDA
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

Displaying **all 2** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase inhibitor activity	IDA
serine-type endopeptidase inhibitor activity	IEA

GO Hierarchy

molecular function

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
membrane	FB:FBrf0231198
extracellular space	PMID:18666829

Ortholog

Displaying entries **1 - 10** of 14 in total

1

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Species	Gene ID	Alliance of Genome Resources
Mus musculus	11905	MGI:88095
Mus musculus	18788	MGI:97609
Caenorhabditis elegans	179195	WB:WBGene00005648
Caenorhabditis elegans	178672	WB:WBGene00005644
Caenorhabditis elegans	178585	WB:WBGene00005642
Caenorhabditis elegans	179125	WB:WBGene00005647
Homo sapiens	647174	HGNC:24774
Homo sapiens	5269	HGNC:8950
Homo sapiens	5055	HGNC:8584
Homo sapiens	462	HGNC:775

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