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opioid related nociceptin receptor 1

Summary

Gene Symbol

OPRL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4987

PubChem

4987

Alliance of Genome Resources

HGNC:8155

Annotation

Keyword

3D-structure
Alternative splicing
Behavior
Cell membrane
Cytoplasmic vesicle
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Palmitate
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q8IXB0	Kappa-type 3 opioid receptor Orphanin FQ receptor
P41146	Kappa-type 3 opioid receptor Orphanin FQ receptor
A0A5F9ZI64	Kappa-type 3 opioid receptor Orphanin FQ receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP	12568343 8137918
phospholipase C-activating G protein-coupled receptor signaling pathway	IPI	10571060
neuropeptide signaling pathway	IBA
sensory perception	TAS	7566152
sensory perception of pain	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

reproductive process [inference]

multicellular organismal reproductive process [inference]

ovulation cycle [inference]

estrous cycle

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

regulation of urine volume [inference]

positive regulation of urine volume

nervous system process [inference]

sensory perception

sensory perception of pain

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

conditioned place preference

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

conditioned place preference

feeding behavior [inference]

eating behavior

rhythmic process [inference]

ovulation cycle [inference]

estrous cycle

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

response to estradiol

response to lipid [inference]

response to estradiol

response to oxygen-containing compound [inference]

response to estradiol

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of circadian rhythm [inference]

regulation of locomotor rhythm

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

regulation of locomotor rhythm

regulation of biological quality [inference]

regulation of blood pressure [inference]

negative regulation of blood pressure

regulation of body fluid levels [inference]

regulation of urine volume [inference]

positive regulation of urine volume

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	12568343 8137918
plasma membrane	IBA
cytoplasmic vesicle	IEA
neuron projection	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nociceptin receptor activity	IDA	10571060 12568343
nociceptin receptor activity	IBA
G protein-coupled receptor activity	IMP	8137918
G protein-coupled receptor activity	IPI	10571060
protein binding	IPI	23597562 28298427 33961781

GO Hierarchy

molecular function

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

neuropeptide binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

nociceptin receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled opioid receptor activity [inference]

nociceptin receptor activity

G protein-coupled peptide receptor activity [inference]

nociceptin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
neuropeptide binding
neuropeptide signaling pathway

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **31 - 40** of 95 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	297795	WB:WBGene00020086
Sus scrofa	397364		PIGXX12170
Canis lupus familiaris	485985		CANLF09775
Macaca mulatta	719224		MACMU01686
Pan troglodytes	747240		PANTR25395
Monodelphis domestica	100024119		MONDO09289
Equus caballus	100051762		HORSE21157
Ornithorhynchus anatinus	100075617		ORNAN25804
Cavia porcellus	100135588		CAVPO22918
Taeniopygia guttata	100219022		TAEGU12215