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pappalysin 1

Summary

Gene Symbol

PAPPA

Organism

Homo sapiens (human)

External Links

NCBI Gene

5069

PubChem

5069

Alliance of Genome Resources

HGNC:8602

Annotation

Keyword

3D-structure
Direct protein sequencing
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Proteomics identification
Reference proteome
Repeat
Secreted
Signal
Sushi
Transmembrane helix
Zinc
Zymogen

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q7Z613
B4DTA8	Insulin-like growth factor-dependent IGF-binding protein 4 protease Pregnancy-associated plasma protein A
Q13219	Insulin-like growth factor-dependent IGF-binding protein 4 protease Pregnancy-associated plasma protein A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
proteolysis	IBA
cell surface receptor signaling pathway	IBA
female pregnancy	NAS	10077652 10913121
protein catabolic process	IEA
response to follicle-stimulating hormone	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

multi-multicellular organism process [inference]

female pregnancy

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to gonadotropin [inference]

response to follicle-stimulating hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to dexamethasone

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to gonadotropin [inference]

response to follicle-stimulating hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to dexamethasone

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to dexamethasone

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to dexamethasone

response to ketone [inference]

response to dexamethasone

response to oxygen-containing compound [inference]

response to ketone [inference]

response to dexamethasone

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region	NAS	10913121
extracellular region	TAS
extracellular region	IDA	10077652
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
metalloendopeptidase activity	EXP	11513734
metalloendopeptidase activity	TAS
metalloendopeptidase activity	IBA
protein binding	IPI	12421832 7685339
metallopeptidase activity	NAS	10913121

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

pappalysin-1

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
cell surface receptor signaling pathway
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 9** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
LamG-like jellyroll fold
Metallopeptidase, catalytic domain superfamily
Myxococcus cysteine-rich repeat
Notch domain
Pappalysin-1/2
Peptidase M43, pregnancy-associated plasma-A
Sushi/SCR/CCP domain
Sushi/SCR/CCP superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:5844	myocardial infarction	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 70 in total

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Species	Gene ID	Orthologous MAtrix
Nannospalax galili	103734508	NANGA02170
Serinus canaria	103819055	SERCA14635
Cercocebus atys	105600495	CERAT22802
Propithecus coquereli	105826414	PROCO08919
Salmo salar	106563270	SALSA14328
Salmo salar	106565903	SALSA68707
Equus asinus asinus	106824182	EQUAS15852
Sinocyclocheilus grahami	107558864	SINGR82200
Sinocyclocheilus grahami	107587665	SINGR23722
Sinocyclocheilus grahami	107595518	SINGR38167

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements