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serpin family A member 5

Summary

Gene Symbol

SERPINA5

Organism

Homo sapiens (human)

External Links

NCBI Gene

5104

PubChem

5104

Alliance of Genome Resources

HGNC:8723

Annotation

Keyword

3D-structure
Direct protein sequencing
Fertilization
Glycoprotein
Heparin-binding
Lipid transport
Reference proteome
Secreted
Serine protease inhibitor
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P05154	Acrosomal serine protease inhibitor Plasminogen activator inhibitor 3 Protein C inhibitor Serpin A5
B4DDH1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
lipid transport	IEA
spermatogenesis	ISS
fusion of sperm to egg plasma membrane involved in single fertilization	NAS	9510955
negative regulation of peptidase activity
negative regulation of hydrolase activity	IMP	8665956

GO Hierarchy

biological process

cellular process [inference]

cellular process involved in reproduction in multicellular organism [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

plasma membrane organization [inference]

plasma membrane fusion [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

membrane fusion [inference]

plasma membrane fusion [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

cellular process involved in reproduction in multicellular organism [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

lipid transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
acrosomal membrane	IDA	7521127 9510955
extracellular region	NAS	14718574
extracellular region	TAS	11120760
extracellular space	IDA	10340997 1725227 8536714 8665956
extracellular space	IBA

GO Hierarchy

cellular component

protein-containing complex

peptidase inhibitor complex [inference]

protease inhibitor complex [inference]

serine protease inhibitor complex [inference]

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

acrosomal membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

acrosomal membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

platelet dense tubular network

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

platelet dense tubular network

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
retinoic acid binding	IDA	11722589
protease binding	IPI	10340997 14696115 15853774 1725227 2844223 3501295 6323392 7521127 8665956 9556620
serine-type endopeptidase inhibitor activity	IDA	10340997 15853774 1725227 2844223 3501295 6323392 7521127 8536714 9510955 9556620
serine-type endopeptidase inhibitor activity	IBA
protein binding	IPI	24388360 7521127 8665956

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylcholine binding

isoprenoid binding [inference]

retinoid binding [inference]

retinoic acid binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

retinoic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

retinoic acid binding

cation binding [inference]

phosphatidylcholine binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serpin

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
serine-type endopeptidase inhibitor activity

Displaying **all 6** entries
InterPro
Serpin domain
Serpin family
Serpin superfamily, domain 1
Serpin superfamily, domain 2
Serpin superfamily
Serpin, conserved site

Ortholog

Displaying entries **1 - 10** of **115** in total

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Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	12	Xenbase:XB-GENE-5933441
Drosophila melanogaster	462	FB:FBgn0038299
Drosophila melanogaster	710	FB:FBgn0031973
Xenopus tropicalis	866	Xenbase:XB-GENE-5933441
Caenorhabditis elegans	1992	WB:WBGene00005649
Drosophila melanogaster	3053	FB:FBgn0038299
Drosophila melanogaster	5054	FB:FBgn0038299
Caenorhabditis elegans	5055	WB:WBGene00005649
Xenopus tropicalis	5104	Xenbase:XB-GENE-5933441
Danio rerio	5265	ZFIN:ZDB-GENE-110407-6