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mitochondrial trans-2-enoyl-CoA reductase

Summary

Gene Symbol

MECR

Aliases

CGI-63
ETR1
FASN2B
NRBF1
mitochondrial 2-enoyl thioester reductase
nuclear receptor binding factor 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

51102

HGNC

19691

KEGG Gene ID

hsa:51102

PubChem

51102

Alliance of Genome Resources

HGNC:19691

JoGo

MECR

TogoVar

MECR

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Disease variant
Dystonia
Fatty acid biosynthesis
Mitochondrion
NADP
Nucleus
Oxidoreductase
Proteomics identification
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BV79	2-enoyl thioester reductase Nuclear receptor-binding factor 1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
fatty acid metabolic process	IDA
fatty acid metabolic process	IMP
fatty acid metabolic process	IBA
fatty acid biosynthetic process
intracellular iron ion homeostasis	IMP

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

small molecule biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

fatty acid metabolic process

fatty acid biosynthetic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

small molecule metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

small molecule biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
cytoplasm	IEA
mitochondrion	IDA
mitochondrion	IBA
mitochondrion	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
oxidoreductase activity	IEA
enoyl-[acyl-carrier-protein] reductase (NADPH) activity	IDA
enoyl-[acyl-carrier-protein] reductase (NADPH) activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [inference]

enoyl-[acyl-carrier-protein] reductase [NAD(P)H] activity [inference]

enoyl-[acyl-carrier-protein] reductase (NADPH) activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000116353

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K07512

Name

mitochondrial enoyl-[acyl-carrier protein] reductase / trans-2-enoyl-CoA reductase [EC:1.3.1.- 1.3.1.38]

References

Rhea

RHEA:22564

NADP⁺

H⁺ + NADPH

Enzyme

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0081419	childhood-onset dystonia with optic atrophy and basal ganglia abnormalities	Alliance of Genome Resources
DOID:5723	optic atrophy	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000407	Sensorineural hearing impairment
HP:0000505	Visual impairment
HP:0000514	Slow saccadic eye movements
HP:0000543	Optic disc pallor
HP:0000551	Color vision defect
HP:0000572	Visual loss
HP:0000580	Pigmentary retinopathy
HP:0000603	Central scotoma
HP:0000639	Nystagmus

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:620629	optic atrophy 16
OMIM:617282	dystonia, childhood-onset, with optic atrophy and basal ganglia abnormalities
ORPHA:508093	dystonia, childhood-onset, with optic atrophy and basal ganglia abnormalities

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001079
Gene Name: mitochondrial trans-2-enoyl-CoA reductase

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements