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proprotein convertase subtilisin/kexin type 5

Summary

Gene Symbol

PCSK5

Organism

Homo sapiens (human)

External Links

NCBI Gene

5125

KEGG Gene ID

PubChem

5125

Alliance of Genome Resources

HGNC:8747

Annotation

Keyword

Alternative splicing
Cleavage on pair of basic residues
Glycoprotein
Pregnancy
Proteomics identification
Reference proteome
Repeat
Secreted
Serine protease
Signal
Transmembrane helix
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A669KA35	Proprotein convertase 5 Proprotein convertase 6 Subtilisin/kexin-like protease PC5
Q92824	Proprotein convertase 5 Proprotein convertase 6 Subtilisin/kexin-like protease PC5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 40 in total

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GO Term	Evidence Code	PMID
kidney development	ISS
kidney development	IMP
kidney development	IEA
renin secretion into blood stream	IEP
cardiac septum development

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process

biosynthetic process [inference]

peptide biosynthetic process

hormone metabolic process [inference]

peptide hormone processing

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling

export from cell [inference]

secretion by cell

protein secretion [inference]

renin secretion into blood stream

signal release [inference]

renin secretion into blood stream

viral process [inference]

viral life cycle

reproductive process [inference]

embryo implantation

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

appendage morphogenesis [inference]

limb morphogenesis

anatomical structure development [inference]

blood vessel development [inference]

coronary vasculature development

cardiac septum development

tube development [inference]

respiratory tube development

digestive tract development [inference]

embryonic digestive tract development

animal organ development [inference]

embryonic organ development [inference]

embryonic digestive tract development

system development [inference]

skeletal system development [inference]

embryonic skeletal system development

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of localization [inference]

transport [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

secretion [inference]

secretion by cell

protein secretion [inference]

renin secretion into blood stream

signal release [inference]

renin secretion into blood stream

export from cell [inference]

secretion by cell

protein secretion [inference]

renin secretion into blood stream

signal release [inference]

renin secretion into blood stream

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of protein catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
Golgi membrane	IBA
extracellular region	ISS
extracellular region	TAS
extracellular region	IEA
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

Golgi lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	EXP
endopeptidase activity	IDA
serine-type endopeptidase activity	IDA
serine-type endopeptidase activity	IBA
serine-type endopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

binding [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

proprotein convertase subtilisin/kexin type 5

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 3** entries
InterPro
EGF-like domain
Furin-like repeat
Growth factor receptor cysteine-rich domain superfamily

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	18552	MGI:97515
Rattus norvegicus	116548	RGD:620326
Caenorhabditis elegans	173051	WB:WBGene00002232
Drosophila melanogaster	32604	FB:FBgn0004598
Saccharomyces cerevisiae S288C	855483	SGD:S000005182

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements