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MIRAGE

procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

Summary

Gene Symbol

PLOD1

Aliases

LH1
lysyl hydroxlase 1
procollagen lysyl hydroxylase 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5351

HGNC

9081

PubChem

5351

Alliance of Genome Resources

HGNC:9081

JoGo

PLOD1

TogoVar

PLOD1

Annotation

Keyword

Alternative splicing
Dioxygenase
Direct protein sequencing
Disease variant
Ehlers-Danlos syndrome
Endoplasmic reticulum
Glycoprotein
Iron
Membrane
Metal-binding
Proteomics identification
Reference proteome
Signal
Vitamin C

Proteins

Displaying 1 entry
UniProt	Protein Name
Q02809	Lysyl hydroxylase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
response to hypoxia	IEP
protein O-linked glycosylation	IDA
epidermis development	IMP
collagen fibril organization	IBA
collagen biosynthetic process	ISS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

collagen biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

collagen metabolic process [inference]

collagen biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
extracellular region	IBA
obsolete extracellular space
endoplasmic reticulum	IBA
endoplasmic reticulum membrane	TAS
Golgi apparatus	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex

cellular anatomical structure [inference]

extracellular region

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

rough endoplasmic reticulum membrane

bounding membrane of organelle [inference]

rough endoplasmic reticulum membrane

external encapsulating structure [inference]

extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
iron ion binding	IEA
protein binding	IPI
procollagen-lysine 5-dioxygenase activity	ISS
procollagen-lysine 5-dioxygenase activity	EXP
procollagen-lysine 5-dioxygenase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

2-oxoglutarate-dependent dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

glucosyltransferase activity [inference]

procollagen glucosyltransferase activity

catalytic activity, acting on a protein [inference]

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

procollagen-lysine 2-oxoglutarate 5-dioxygenase 2

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 7** entries
Gene Ontology
L-ascorbic acid binding
dioxygenase activity
iron ion binding
metal ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
procollagen-lysine 5-dioxygenase activity

Displaying **all 5** entries
InterPro
Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain
Nucleotide-diphospho-sugar transferases
Oxoglutarate/iron-dependent dioxygenase
Procollagen-lysine 5-dioxygenase, conserved site
Prolyl 4-hydroxylase, alpha subunit

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080734	Ehlers-Danlos syndrome kyphoscoliotic type 1	Glyco-Disease Genes Database Alliance of Genome Resources
DOID:14775	brittle cornea syndrome 1	Glyco-Disease Genes Database

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026