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Guidelines

MIRAGE

PMS1 homolog 1, mismatch repair system component

Summary

Gene Symbol

PMS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5378

KEGG Gene ID

PubChem

5378

Alliance of Genome Resources

HGNC:9121

Annotation

Keyword

3D-structure
Alternative splicing
DNA damage
DNA repair
DNA-binding
Hereditary nonpolyposis colorectal cancer
Nucleus
Proteomics identification
Reference proteome
Tumor suppressor

Proteins

Displaying **all 7** entries
UniProt	Protein Name
P54277	DNA mismatch repair protein PMS1
B7ZAA0
E9PC40
Q3BDU3
B4DIH7
Q5XG96
I6L9H5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mismatch repair	TAS
mismatch repair	IBA
mismatch repair	IEA
response to xenobiotic stimulus	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

mismatch repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

mismatch repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

mismatch repair

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

mismatch repair

response to chemical [inference]

response to xenobiotic stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

mismatch repair

Displaying entries **6 - 7** of 7 in total

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2
GO Term	Evidence Code	PMID
mismatch repair complex	IEA
MutLalpha complex

GO Hierarchy

cellular component

protein-containing complex [inference]

mismatch repair complex

MutLalpha complex

nuclear protein-containing complex [inference]

MutLalpha complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 8 in total

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2

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GO Term	Evidence Code	PMID
DNA binding	TAS
protein binding	IPI
ATP binding	IEA
ATP hydrolysis activity	IBA
ATP hydrolysis activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

ATP-dependent DNA damage sensor activity

binding [inference]

nucleic acid binding [inference]

double-stranded DNA binding [inference]

mismatched DNA binding

protein binding

enzyme binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular function regulator activity [inference]

molecular sensor activity [inference]

DNA damage sensor activity [inference]

ATP-dependent DNA damage sensor activity

ATP-dependent activity [inference]

ATP-dependent activity, acting on DNA [inference]

ATP-dependent DNA damage sensor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

PMS1

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ATP binding
ATP-dependent DNA damage sensor activity

Displaying **all 9** entries
InterPro
DNA mismatch repair protein MutL/Mlh/PMS
DNA mismatch repair protein MutL/Mlh/Pms-like
DNA mismatch repair protein, S5 domain 2-like
DNA mismatch repair, conserved site
High mobility group box domain superfamily
High mobility group box domain
Histidine kinase/HSP90-like ATPase superfamily
Ribosomal protein uS5 domain 2-type superfamily
Small ribosomal subunit protein uS5 domain 2-type fold, subgroup

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:3883	Lynch syndrome	Alliance of Genome Resources
DOID:10223	dermatomyositis	Alliance of Genome Resources
DOID:0080745	polymyositis	Alliance of Genome Resources
DOID:3587	pancreatic ductal carcinoma	Alliance of Genome Resources

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026