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Guidelines

MIRAGE

inducible T cell co-stimulator

Summary

Gene Symbol

Icos

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

54167

KEGG Gene ID

PubChem

54167

Alliance of Genome Resources

MGI:1858745

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q5SUZ7	Activation-inducible lymphocyte immunomediatory molecule
Q9WVS0	Activation-inducible lymphocyte immunomediatory molecule CD28 and CTLA-4-like protein CD28-related protein 1
Q3V3X2	Activation-inducible lymphocyte immunomediatory molecule

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
T cell tolerance induction	ISO
T cell tolerance induction	IBA
T cell costimulation	ISO
T cell costimulation	IBA
T cell costimulation	IEA

GO Hierarchy

biological process

immune system process [inference]

tolerance induction [inference]

T cell tolerance induction

lymphocyte costimulation [inference]

T cell costimulation

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell activation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell activation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

cell adhesion [inference]

cell-cell adhesion

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell activation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	IDA
plasma membrane	IEA
external side of plasma membrane	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI
signaling receptor activity	ISO
signaling receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:12177	common variable immunodeficiency	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	64545	RGD:620123
Homo sapiens	29851	HGNC:5351

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Last updated: April 6, 2026