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DNA polymerase alpha 1, catalytic subunit

Summary

Gene Symbol

POLA1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5422

PubChem

5422

Alliance of Genome Resources

HGNC:9173

JoGo

POLA1

TogoVar

POLA1

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
DNA replication
DNA-binding
DNA-directed DNA polymerase
Direct protein sequencing
Disease variant
Dwarfism
Host-virus interaction
Intellectual disability
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P09884	DNA polymerase alpha catalytic subunit p180
A6NMQ1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
DNA synthesis involved in DNA repair	IMP	11470886
DNA synthesis involved in DNA repair	IBA
DNA replication	IMP	16762037 31006512 3917431 4084590
DNA replication	IEA
DNA-templated DNA replication	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of primer

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of primer

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

cell cycle process [inference]

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

mitotic cell cycle process [inference]

mitotic DNA replication initiation

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of type I interferon production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of type I interferon production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of type I interferon production

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
chromatin	IDA	9815285
nucleus	IDA	16762037 4084590
nucleus	IEA
nuclear envelope	IDA	9518481
nucleoplasm	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

alpha DNA polymerase:primase complex

intracellular protein-containing complex [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

alpha DNA polymerase:primase complex

DNA polymerase complex [inference]

alpha DNA polymerase:primase complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

alpha DNA polymerase:primase complex

DNA polymerase complex [inference]

alpha DNA polymerase:primase complex

cellular anatomical structure [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nucleolus

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
nucleotide binding	IDA	3139084
nucleotide binding	IEA
nucleic acid binding	IEA
DNA binding	IDA	16762037
DNA binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

DNA polymerase activity

DNA-directed DNA polymerase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA polymerase activity

DNA-directed DNA polymerase activity

binding [inference]

nucleic acid binding

DNA binding

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

DNA replication origin binding

single-stranded DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

DNA replication origin binding

chromatin binding

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

heterocyclic compound binding [inference]

nucleotide binding

nucleoside phosphate binding [inference]

nucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dna polymerase

Functional Category

L: Replication, recombination and repair
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 10** entries
Gene Ontology
DNA biosynthetic process
DNA replication origin binding
chromatin binding
lagging strand elongation
leading strand elongation
metal ion binding
mitotic DNA replication initiation
nucleotide binding
nucleotidyltransferase activity
transferase activity

Displaying entries **1 - 10** of 13 in total

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InterPro
DNA polymerase alpha catalytic subunit, N-terminal domain
DNA polymerase alpha catalytic subunit, catalytic domain
DNA polymerase alpha, zinc finger domain superfamily
DNA polymerase family B, thumb domain
DNA polymerase, palm domain superfamily
DNA-directed DNA polymerase, family B, conserved site
DNA-directed DNA polymerase, family B, exonuclease domain
DNA-directed DNA polymerase, family B, multifunctional domain
DNA-directed DNA polymerase, family B
DNA/RNA polymerase superfamily