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DNA polymerase epsilon 2, accessory subunit

Summary

Gene Symbol

POLE2

Organism

Homo sapiens (human)

External Links

NCBI Gene

5427

KEGG Gene ID

[""]

PubChem

5427

Alliance of Genome Resources

HGNC:9178

Annotation

Keyword

3D-structure
Alternative splicing
DNA replication
DNA-binding
Nucleus
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P56282	DNA polymerase II subunit 2 DNA polymerase epsilon subunit B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
DNA metabolic process	IEA
DNA replication	TAS
DNA replication	IEA
DNA-templated DNA replication	IDA
DNA-templated DNA replication	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA replication [inference]

translesion synthesis [inference]

error-prone translesion synthesis

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA replication [inference]

translesion synthesis [inference]

error-prone translesion synthesis

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA replication [inference]

translesion synthesis [inference]

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process

DNA replication

DNA-templated DNA replication

DNA repair

DNA damage tolerance [inference]

translesion synthesis [inference]

error-prone translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA replication [inference]

translesion synthesis [inference]

error-prone translesion synthesis

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA replication [inference]

translesion synthesis [inference]

error-prone translesion synthesis

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA replication [inference]

translesion synthesis [inference]

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process

DNA replication

DNA-templated DNA replication

DNA repair

DNA damage tolerance [inference]

translesion synthesis [inference]

error-prone translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA replication [inference]

translesion synthesis [inference]

error-prone translesion synthesis

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA replication [inference]

translesion synthesis [inference]

error-prone translesion synthesis

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

DNA damage tolerance [inference]

translesion synthesis [inference]

error-prone translesion synthesis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

DNA damage tolerance [inference]

translesion synthesis [inference]

error-prone translesion synthesis

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

DNA damage tolerance [inference]

translesion synthesis [inference]

error-prone translesion synthesis

Displaying entries **1 - 5** of 10 in total

1

2

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GO Term	Evidence Code	PMID
nucleus	IEA
nucleoplasm	TAS
nucleoplasm	IDA
chromosome	IEA
epsilon DNA polymerase complex	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

epsilon DNA polymerase complex

intracellular protein-containing complex [inference]

DNA polymerase complex [inference]

epsilon DNA polymerase complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

DNA polymerase complex [inference]

epsilon DNA polymerase complex

cellular anatomical structure [inference]

nucleoplasm

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

nuclear lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
DNA binding	IEA
DNA-directed DNA polymerase activity	TAS
protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

binding [inference]

nucleic acid binding [inference]

DNA binding

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA polymerase

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
error-prone translesion synthesis

Displaying **all 2** entries
InterPro
DNA polymerase alpha/delta/epsilon, subunit B
DNA polymerase epsilon, subunit B

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026

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