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solute carrier family 12 member 3

Summary

Gene Symbol

Slc12a3

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

54300

PubChem

54300

Alliance of Genome Resources

RGD:3686

Annotation

Keyword

ATP-binding
Cell membrane
Chloride
Disulfide bond
Glycoprotein
Metal-binding
Phosphoprotein
Reference proteome
Sodium transport
Symport
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
G3V8G0
P55018	Na-Cl symporter Thiazide-sensitive sodium-chloride cotransporter
A6JY68

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 25** of 26 in total

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GO Term	Evidence Code	PMID
renal sodium ion absorption	IEA
chloride transmembrane transport	IBA
chloride transmembrane transport	IEA
response to aldosterone	ISO
response to aldosterone	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal sodium ion transport [inference]

renal sodium ion absorption

renal absorption [inference]

renal sodium ion absorption

multicellular organismal-level homeostasis [inference]

energy homeostasis [inference]

response to dietary excess

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis

multicellular organismal-level homeostasis [inference]

energy homeostasis [inference]

response to dietary excess

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

monoatomic anion homeostasis [inference]

chloride ion homeostasis

inorganic ion homeostasis [inference]

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to dietary excess

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid [inference]

response to aldosterone

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid [inference]

response to aldosterone

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid [inference]

response to aldosterone

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid [inference]

response to aldosterone

response to alcohol [inference]

response to aldosterone

response to ketone [inference]

response to aldosterone

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to aldosterone

response to ketone [inference]

response to aldosterone

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

sodium ion transport

renal sodium ion transport [inference]

renal sodium ion absorption

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic anion transport [inference]

chloride transport

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
cytosol	ISO
cytosol	IEA
plasma membrane	ISO
plasma membrane	IDA	16275913 16887815
apical plasma membrane	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
sodium:chloride symporter activity	IDA	10894798 16624820
sodium:chloride symporter activity	IMP	8021284
sodium:chloride symporter activity	IEA
enzyme binding	IPI	11832422
metal ion binding	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

sodium ion transmembrane transporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

sodium ion transmembrane transporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

sodium ion transmembrane transporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

binding [inference]

protein binding [inference]

enzyme binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

solute carrier family 12 member

Functional Category

E: Amino acid transport and metabolism
K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
cell volume homeostasis
chloride ion homeostasis
chloride transmembrane transport
chloride
monoatomic ion transport
potassium ion homeostasis

Displaying **all 3** entries
InterPro
Amino acid permease/ SLC12A domain
SLC12A transporter family
SLC12A transporter, C-terminal

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
vesicle	PMID:16554416
apical plasma membrane	PMID:16554416

Ortholog

Displaying entries **61 - 70** of 77 in total

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Species	Gene ID	Orthologous MAtrix
Rhinopithecus bieti	108533863	RHIBE12101
Phascolarctos cinereus	110193769	PHACI10176
Sus scrofa	110260927	PIGXX27216
Pseudonaja textilis	113445271	PSETE18170
Electrophorus electricus	113589789	ELEEL43811
Bos indicus x Bos taurus	113876824	BOBOX12974
Vombatus ursinus	114048552	VOMUR15118
Podarcis muralis	114601770	PODMU33037
Echeneis naucrates	115057064	ECHNA52378
Salmo trutta	115196823	SALTR12213

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Acknowledgements