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dolichyl-phosphate mannosyltransferase subunit 3, regulatory

Summary

Gene Symbol

DPM3

Aliases

DPM synthase complex subunit
MGC125904
MGC125905
MGC34275

Organism

Homo sapiens (human)

External Links

NCBI Gene

54344

GGDB ID

gg204

HGNC

3007

mRNA

NM_018973

map

1q22

Protein

NP_061846

OMIM

605951

KEGG Gene ID

hsa:54344

PubChem

54344

Alliance of Genome Resources

HGNC:3007

JoGo

DPM3

TogoVar

DPM3

Annotation

Keyword

Alternative splicing
Congenital disorder of glycosylation
Congenital muscular dystrophy
Direct protein sequencing
Disease variant
Dystroglycanopathy
Endoplasmic reticulum
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9P2X0	Dolichol-phosphate mannose synthase subunit 3 Dolichyl-phosphate beta-D-mannosyltransferase subunit 3 Mannose-P-dolichol synthase subunit 3 Prostin-1
A0A140VJI4
Q86TM7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
glycoprotein biosynthetic process	IEA
protein O-linked glycosylation via mannose	ISS
dolichyl monophosphate biosynthetic process	IDA
dolichol phosphate mannose biosynthetic process	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

biosynthetic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

dolichol phosphate mannose biosynthetic process

phospholipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

dolichol phosphate mannose biosynthetic process

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

glycolipid biosynthetic process [inference]

dolichol phosphate mannose biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

terpenoid biosynthetic process [inference]

dolichol phosphate mannose biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

dolichol phosphate mannose biosynthetic process

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

dolichol phosphate mannose biosynthetic process

phospholipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

dolichol phosphate mannose biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process [inference]

dolichol phosphate mannose biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

glycolipid biosynthetic process [inference]

dolichol phosphate mannose biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process [inference]

dolichol phosphate mannose biosynthetic process

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA
endoplasmic reticulum membrane	NAS
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IDA
endoplasmic reticulum membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

mannosyltransferase complex [inference]

dolichol-phosphate-mannose synthase complex

catalytic complex [inference]

transferase complex [inference]

mannosyltransferase complex [inference]

dolichol-phosphate-mannose synthase complex

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI
enzyme activator activity	IDA
protein-membrane adaptor activity	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

protein-membrane adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity

molecular function activator activity [inference]

enzyme activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
InterPro
Dolichol-phosphate mannosyltransferase subunit 3

Human Protein Atlas

ENSG00000179085

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg204

Gene Symbol

DPM3

Orthologous Gene

Displaying 1 entry
Species	Protein	mRNA
Mus musculus	NP_081043	NM_026767

KEGG BRITE Database

Orthology

K09659

Name

dolichol-phosphate mannosyltransferase subunit 3

References

10835346

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050570	congenital disorder of glycosylation type I	Alliance of Genome Resources
DOID:0112376	muscular dystrophy-dystroglycanopathy type B15	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 31 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0001270	Motor delay
HP:0001315	Reduced tendon reflexes
HP:0001324	Muscle weakness
HP:0001644	Dilated cardiomyopathy
HP:0001763	Pes planus
HP:0002121	Generalized non-motor (absence) seizure
HP:0002187	Intellectual disability, profound
HP:0002317	Unsteady gait
HP:0002401	Stroke-like episode

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:612937	DPM3-congenital disorder of glycosylation
ORPHA:263494	DPM3-congenital disorder of glycosylation
OMIM:618992	muscular dystrophy-dystroglycanopathy (congenital with impaired intellectual development), type B, 15

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006110
Gene Name: dolichyl-phosphate mannosyltransferase polypeptide 3

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements