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paraoxonase 3
Summary
- Gene Symbol
-
- PON3
- Aliases
-
- arylesterase 3
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Calcium
- Disulfide bond
- Glycoprotein
- Hydrolase
- Metal-binding
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Secreted
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| Q15166 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| renal sodium ion transport |
|
|
| response to toxic substance |
|
|
| negative regulation of superoxide anion generation |
|
|
| carboxylic acid catabolic process |
|
|
| carboxylic acid catabolic process |
|
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region |
|
|
| extracellular region |
|
|
| extracellular region |
|
|
| obsolete extracellular space |
|
|
| endoplasmic reticulum membrane |
|
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| aryldialkylphosphatase activity |
|
|
| arylesterase activity |
|
|
| arylesterase activity |
|
|
| arylesterase activity |
|
|
| arylesterase activity |
|
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- serum paraoxonase/arylesterase
- Functional Category
-
- G: Carbohydrate transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| arylesterase activity |
| hydrolase activity |
| metal ion binding |
| response to toxic substance |
| InterPro |
|---|
| Arylesterase |
| Six-bladed beta-propeller, TolB-like |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10652 | Alzheimer's disease | |
| DOID:1936 | atherosclerosis | |
| DOID:332 | amyotrophic lateral sclerosis |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000217 | Xerostomia |
| HP:0000708 | Atypical behavior |
| HP:0000712 | Emotional lability |
| HP:0000713 | Agitation |
| HP:0000716 | Depression |
| HP:0000739 | Anxiety |
| HP:0001257 | Spasticity |
| HP:0001260 | Dysarthria |
| HP:0001347 | Hyperreflexia |
| HP:0002015 | Dysphagia |
| Disease ID | Disease Name |
|---|---|
| ORPHA:803 |
|
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP003770
- Gene Name
- paraoxonase 3
