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Guidelines

MIRAGE

UDP glucuronosyltransferase family 1 member A4

Summary

Gene Symbol

UGT1A4

Aliases

HUG-BR2
UGT1D

Organism

Homo sapiens (human)

External Links

NCBI Gene

54657

HGNC

12536

KEGG Gene ID

hsa:54657

PubChem

54657

Alliance of Genome Resources

HGNC:12536

JoGo

UGT1A4

TogoVar

UGT1A4

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Lipid metabolism
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P22310	Bilirubin-specific UDPGT isozyme 2 UDP-glucuronosyltransferase 1-4 UDP-glucuronosyltransferase 1-D

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
liver development	IBA
bilirubin conjugation	TAS
xenobiotic metabolic process	IKR
xenobiotic metabolic process	IMR
steroid metabolic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

xenobiotic metabolic process

xenobiotic catabolic process

catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

xenobiotic catabolic process

flavonoid metabolic process [inference]

flavone metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme metabolic process [inference]

heme catabolic process

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

pigment metabolic process [inference]

heme metabolic process [inference]

heme catabolic process

pigment catabolic process [inference]

heme catabolic process

flavone metabolic process

hormone metabolic process [inference]

estrogen metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

vitamin D metabolic process [inference]

vitamin D3 metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

vitamin D3 metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process

glucuronate metabolic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

gland development [inference]

liver development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

cellular response to glucocorticoid stimulus

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

response to chemical [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

cellular response to glucocorticoid stimulus

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

cellular response to glucocorticoid stimulus

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process

regulation of ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process

regulation of small molecule metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

estrogen metabolic process

detoxification

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IMR
endoplasmic reticulum membrane	IKR
endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
retinoic acid binding	IDA
enzyme inhibitor activity	ISS
enzyme inhibitor activity	IBA
UDP-glycosyltransferase activity	IBA
UDP-glycosyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity

glucuronosyltransferase activity

hexosyltransferase activity [inference]

glucuronosyltransferase activity

binding [inference]

protein binding [inference]

enzyme binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

lipid binding [inference]

isoprenoid binding [inference]

retinoid binding [inference]

retinoic acid binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

retinoic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

retinoic acid binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

glucuronosyltransferase

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
UDP-glycosyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
UDP-glucuronosyl/UDP-glucosyltransferase
UDP-glycosyltransferase family, conserved site

KEGG BRITE Database

Orthology

K00699

Name

glucuronosyltransferase [EC:2.4.1.17]

References

Rhea

glucuronate acceptor + UDP-α-D-glucuronate

acceptor β-D-glucuronoside + H⁺ + UDP

Enzyme

2.4.1.17

PMID

Ortholog

Displaying entries **1 - 10** of 25 in total

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Species	Gene ID	Alliance of Genome Resources
Mus musculus	394433	MGI:3032634
Rattus norvegicus	574523	RGD:1583689
Caenorhabditis elegans	179446	WB:WBGene00007070
Caenorhabditis elegans	185500	WB:WBGene00018206
Drosophila melanogaster	35105	FB:FBgn0032684
Drosophila melanogaster	35137	FB:FBgn0027074
Drosophila melanogaster	35138	FB:FBgn0032713
Drosophila melanogaster	35139	FB:FBgn0027070
Drosophila melanogaster	40079	FB:FBgn0036842
Drosophila melanogaster	41334	FB:FBgn0026315

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026