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Guidelines

MIRAGE

phosphatidylinositol glycan anchor biosynthesis class G (EMM blood group)

Summary

Gene Symbol

PIGG

Aliases

FLJ20265
GPI ethanolamine phosphate transferase 2
GPI7
LAS21
LAS21 (GPI7) homolog (S. cerevisiae)

Organism

Homo sapiens (human)

External Links

NCBI Gene

54872

GGDB ID

gg229

HGNC

25985

mRNA

NM_001127178

map

4p16.3

Protein

NP_001120650

KEGG Gene ID

hsa:54872

PubChem

54872

Alliance of Genome Resources

HGNC:25985

JoGo

PIGG

TogoVar

PIGG

Annotation

Keyword

Alternative splicing
Disease variant
Endoplasmic reticulum
GPI-anchor biosynthesis
Glycoprotein
Intellectual disability
Proteomics identification
Reference proteome
Transferase
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
E7EWV1
D6RFE8
Q5H8A4	GPI7 homolog Phosphatidylinositol-glycan biosynthesis class G protein
Q8NCI4
E7EM50

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
GPI anchor biosynthetic process	TAS
GPI anchor biosynthetic process	IDA
GPI anchor biosynthetic process	IBA
GPI anchor biosynthetic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA
endoplasmic reticulum membrane	EXP
endoplasmic reticulum membrane	NAS
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
transferase activity	IMP
phosphotransferase activity, for other substituted phosphate groups	TAS
obsolete CP2 mannose-ethanolamine phosphotransferase activity
mannose-ethanolamine phosphotransferase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

transferase activity, transferring phosphorus-containing groups [inference]

phosphotransferase activity, for other substituted phosphate groups

mannose-ethanolamine phosphotransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg229

Gene Symbol

PIGG

KEGG BRITE Database

Orthology

K05310

Name

ethanolamine phosphate transferase 2 subunit G [EC:2.7.-.-]

References

15632136

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05924	2.7.-.-	G96147ST	G56360MU

Disease

The Human Phenotype Ontology

Displaying entries **1 - 10** of **120** in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000028	Cryptorchidism
HP:0000047	Hypospadias
HP:0000077	Abnormality of the kidney
HP:0000078	Abnormality of the genital system
HP:0000079	Abnormality of the urinary system
HP:0000153	Abnormality of the mouth
HP:0000159	Abnormal lip morphology
HP:0000175	Cleft palate
HP:0000204	Cleft upper lip

Displaying **all 3** entries
Disease ID	Disease Name
ORPHA:280	Wolf-Hirschhorn syndrome
OMIM:616917	intellectual disability, autosomal recessive 53
ORPHA:488635	intellectual disability, autosomal recessive 53

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006740
Gene Name: phosphatidylinositol glycan anchor biosynthesis, class G

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	433931	MGI:3576484
Saccharomyces cerevisiae S288C	853384	SGD:S000003598

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026