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MIRAGE
CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase
Summary
- Gene Symbol
-
- CDKAL1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 4Fe-4S
- Alternative splicing
- Diabetes mellitus
- Endoplasmic reticulum
- Phosphoprotein
- Proteomics identification
- Reference proteome
- S-adenosyl-L-methionine
- Transferase
- Transmembrane helix
- tRNA processing
- Proteins
| UniProt | Protein Name |
|---|---|
| Q5VV42 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| tRNA modification |
|
|
| biological_process |
|
|
| tRNA methylthiolation |
|
|
| maintenance of translational fidelity |
|
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| endoplasmic reticulum |
|
|
| endoplasmic reticulum |
|
|
| endoplasmic reticulum membrane |
|
|
| endoplasmic reticulum membrane |
|
|
| endoplasmic reticulum membrane |
|
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| catalytic activity |
|
|
| protein binding |
|
|
| transferase activity |
|
|
| methylthiotransferase activity |
|
|
| tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity |
|
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1
- Functional Category
-
- E: Amino acid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| 4 iron, 4 sulfur cluster binding |
| catalytic activity |
| iron-sulfur cluster binding |
| metal ion binding |
| methylthiotransferase activity |
| tRNA methylthiolation |
| transferase activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:11714 | gestational diabetes | |
| DOID:8947 | diabetic retinopathy | |
| DOID:9351 | diabetes mellitus | |
| DOID:9352 | type 2 diabetes mellitus |
