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ubiquitin like modifier activating enzyme 6

Summary

Gene Symbol

UBA6

Organism

Homo sapiens (human)

External Links

NCBI Gene

55236

PubChem

55236

Alliance of Genome Resources

HGNC:25581

JoGo

UBA6

TogoVar

UBA6

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Ligase
Magnesium
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
A0AVT1	Monocyte protein 4 Ubiquitin-activating enzyme E1-like protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
ubiquitin-dependent protein catabolic process	IMP	17889673
ubiquitin-dependent protein catabolic process	IBA	http://purl.obolibrary.org/obo/go/references/0000033
ubiquitin-dependent protein catabolic process	IEA	http://purl.obolibrary.org/obo/go/references/0000107 http://purl.obolibrary.org/obo/go/references/0000117
cellular response to DNA damage stimulus	IBA	http://purl.obolibrary.org/obo/go/references/0000033
DNA damage response	IBA	http://purl.obolibrary.org/obo/go/references/0000033

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleus	IBA	http://purl.obolibrary.org/obo/go/references/0000033
nucleoplasm	IDA
cytoplasm	IDA	http://purl.obolibrary.org/obo/go/references/0000054
cytoplasm	IBA
cytosol	TAS	https://reactome.org/content/detail/R-HSA-8852127

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

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GO Term	Evidence Code	PMID
ubiquitin activating enzyme activity	IBA
ubiquitin activating enzyme activity	IEA	http://purl.obolibrary.org/obo/go/references/0000003 http://purl.obolibrary.org/obo/go/references/0000107
protein binding	IPI	17889673 25416956 25422469
ATP binding
ubiquitin-like modifier activating enzyme activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming carbon-sulfur bonds [inference]

ubiquitin-like modifier activating enzyme activity

catalytic activity, acting on a protein [inference]

ubiquitin-like modifier activating enzyme activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

ubiquitin-like modifier activating enzyme activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ubiquitin activating enzyme

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 5** entries
Gene Ontology
ATP binding
ligase activity
nucleotide binding
protein ubiquitination
ubiquitin activating enzyme activity

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InterPro
THIF-type NAD/FAD binding fold
ThiF/MoeB/HesA family
Ubiquitin-activating enzyme E1, C-terminal domain superfamily
Ubiquitin-activating enzyme E1, C-terminal
Ubiquitin-activating enzyme E1, Cys active site
Ubiquitin-activating enzyme E1, FCCH domain superfamily
Ubiquitin-activating enzyme E1, FCCH domain
Ubiquitin-activating enzyme E1, SCCH domain
Ubiquitin-activating enzyme E1, four-helix bundle
Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1