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RNA polymerase III subunit B

Summary

Gene Symbol

POLR3B

Organism

Homo sapiens (human)

External Links

NCBI Gene

55703

PubChem

55703

Alliance of Genome Resources

HGNC:30348

JoGo

POLR3B

TogoVar

POLR3B

Annotation

Keyword

3D-structure
Alternative splicing
Antiviral defense
Charcot-Marie-Tooth disease
Cytoplasm
DNA-directed RNA polymerase
Disease variant
Innate immunity
Leukodystrophy
Magnesium
Neurodegeneration
Nucleotidyltransferase
Nucleus
Proteomics identification
Reference proteome
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NW08	C128 DNA-directed RNA polymerase III 127.6 kDa polypeptide DNA-directed RNA polymerase III subunit B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
transcription, DNA-templated	IEA
DNA-templated transcription	IEA
DNA-templated transcription elongation	IBA
transcription by RNA polymerase III	IDA
transcription by RNA polymerase III	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III

snRNA transcription by RNA polymerase III

snRNA transcription [inference]

snRNA transcription by RNA polymerase III

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase III promoter

DNA-templated transcription termination [inference]

termination of RNA polymerase III transcription

DNA-templated transcription elongation

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III

snRNA transcription by RNA polymerase III

snRNA transcription [inference]

snRNA transcription by RNA polymerase III

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase III promoter

DNA-templated transcription termination [inference]

termination of RNA polymerase III transcription

DNA-templated transcription elongation

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III

snRNA transcription by RNA polymerase III

snRNA transcription [inference]

snRNA transcription by RNA polymerase III

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase III promoter

DNA-templated transcription termination [inference]

termination of RNA polymerase III transcription

DNA-templated transcription elongation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA transcription [inference]

snRNA transcription by RNA polymerase III

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III

snRNA transcription by RNA polymerase III

snRNA transcription [inference]

snRNA transcription by RNA polymerase III

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase III promoter

DNA-templated transcription termination [inference]

termination of RNA polymerase III transcription

DNA-templated transcription elongation

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III

snRNA transcription by RNA polymerase III

snRNA transcription [inference]

snRNA transcription by RNA polymerase III

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase III promoter

DNA-templated transcription termination [inference]

termination of RNA polymerase III transcription

DNA-templated transcription elongation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III

snRNA transcription by RNA polymerase III

snRNA transcription [inference]

snRNA transcription by RNA polymerase III

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase III promoter

DNA-templated transcription termination [inference]

termination of RNA polymerase III transcription

DNA-templated transcription elongation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA transcription [inference]

snRNA transcription by RNA polymerase III

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III

snRNA transcription by RNA polymerase III

snRNA transcription [inference]

snRNA transcription by RNA polymerase III

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase III promoter

DNA-templated transcription termination [inference]

termination of RNA polymerase III transcription

DNA-templated transcription elongation

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III

snRNA transcription by RNA polymerase III

snRNA transcription [inference]

snRNA transcription by RNA polymerase III

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase III promoter

DNA-templated transcription termination [inference]

termination of RNA polymerase III transcription

DNA-templated transcription elongation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response

positive regulation of immune response [inference]

positive regulation of innate immune response

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response

positive regulation of defense response [inference]

positive regulation of innate immune response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response

positive regulation of immune response [inference]

positive regulation of innate immune response

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response

positive regulation of defense response [inference]

positive regulation of innate immune response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response

positive regulation of immune response [inference]

positive regulation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response

positive regulation of immune response [inference]

positive regulation of innate immune response

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of type I interferon production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of interferon-beta production [inference]

positive regulation of interferon-beta production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of type I interferon production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of interferon-beta production [inference]

positive regulation of interferon-beta production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of type I interferon production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of interferon-beta production [inference]

positive regulation of interferon-beta production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
DNA-directed RNA polymerase complex	IEA
nucleus	NAS
nucleus	IEA
nucleoplasm	TAS
RNA polymerase III complex	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

intracellular protein-containing complex [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

nuclear lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
DNA binding	IEA
DNA-directed RNA polymerase activity	IDA
DNA-directed RNA polymerase activity	IEA
zinc ion binding	IDA
zinc ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

RNA polymerase activity [inference]

5'-3' RNA polymerase activity

DNA-directed RNA polymerase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA polymerase activity [inference]

5'-3' RNA polymerase activity

DNA-directed RNA polymerase activity

binding [inference]

nucleic acid binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

heterocyclic compound binding [inference]

nucleoside binding [inference]

ribonucleoside binding

carbohydrate derivative binding [inference]

nucleoside binding [inference]

ribonucleoside binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dna-directed rna polymerase i

Functional Category

H: Coenzyme transport and metabolism
J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
metal ion binding
nucleotidyltransferase activity
ribonucleoside binding
transferase activity

Displaying entries **1 - 10** of 12 in total

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InterPro
DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
DNA-directed RNA polymerase, subunit 2
RNA polymerase Rpb2, OB-fold
RNA polymerase Rpb2, domain 2 superfamily
RNA polymerase Rpb2, domain 2
RNA polymerase Rpb2, domain 3
RNA polymerase Rpb2, domain 4
RNA polymerase Rpb2, domain 5
RNA polymerase Rpb2, domain 7

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060797	hypomyelinating leukodystrophy 8	Alliance of Genome Resources
DOID:10595	Charcot-Marie-Tooth disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements