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ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase

Summary

Gene Symbol

ALG1

Aliases

CDG1K
HMAT1
HMT-1
Mat-1

Organism

Homo sapiens (human)

External Links

NCBI Gene

56052

GGDB ID

gg142

HGNC

18294

mRNA

NM_019109

map

16p13.3

Protein

NP_061982

OMIM

605907

KEGG Gene ID

["hsa:56052"]

PubChem

56052

Alliance of Genome Resources

HGNC:18294

JoGo

ALG1

TogoVar

ALG1

Annotation

Keyword

Alternative splicing
Congenital disorder of glycosylation
Disease variant
Endoplasmic reticulum
Glycosyltransferase
Phosphoprotein
Proteomics identification
Reference proteome
Signal
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9BT22	Asparagine-linked glycosylation protein 1 homolog Beta-1,4-mannosyltransferase GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase GDP-mannose-dolichol diphosphochitobiose mannosyltransferase Mannosyltransferase-1
A0A804HJL6	Asparagine-linked glycosylation protein 1 homolog Beta-1,4-mannosyltransferase GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase GDP-mannose-dolichol diphosphochitobiose mannosyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein N-linked glycosylation	IDA
dolichol-linked oligosaccharide biosynthetic process	TAS
dolichol-linked oligosaccharide biosynthetic process	IDA
glycoprotein biosynthetic process	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycoprotein biosynthetic process

protein N-linked glycosylation

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycoprotein biosynthetic process

protein N-linked glycosylation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA
endoplasmic reticulum membrane	ISS
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IEA
membrane	HDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of endoplasmic reticulum membrane

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GO Term	Evidence Code	PMID
mannosyltransferase activity	IBA
mannosyltransferase activity	IEA
chitobiosyldiphosphodolichol beta-mannosyltransferase activity	TAS
chitobiosyldiphosphodolichol beta-mannosyltransferase activity	IDA
chitobiosyldiphosphodolichol beta-mannosyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

hexosyltransferase activity [inference]

mannosyltransferase activity

beta-1,4-mannosyltransferase activity [inference]

chitobiosyldiphosphodolichol beta-mannosyltransferase activity

GlcNAc(2)-PP-Dol mannosyltransferase activity [inference]

chitobiosyldiphosphodolichol beta-mannosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Mannosyltransferase

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
mannosyltransferase activity
transferase activity

Displaying 1 entry
InterPro
Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1-like

Human Protein Atlas

ENSG00000033011

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg142

Gene Symbol

ALG1

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
GDP-Man	G05026ZL		G65996GC

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
GDP-Man	G05026ZL		G65996GC

Orthologous Gene

Displaying **all 5** entries
Species	Protein	mRNA
Caenorhabditis elegans	NP_498420	NM_066019
Mus musculus	NP_663337	NM_145362
Saccharomyces cerevisiae	CAA85067	Z35979
Drosophila melanogaster	NP_650662	NM_142405
Rattus norvegicus	XP_340751	XM_340751

KEGG BRITE Database

Orthology

K03842

Name

beta-1,4-mannosyltransferase [EC:2.4.1.142]

References

10704531

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05972	2.4.1.142	G05026ZL	G65996GC

Rhea

RHEA:13865

GDP-α-D-mannose

H⁺ + GDP

Enzyme

2.4.1.142

PMID

6215245

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080563	congenital disorder of glycosylation Ik	Glyco-Disease Genes Database Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 50 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000077	Abnormality of the kidney
HP:0000083	Renal insufficiency
HP:0000100	Nephrotic syndrome
HP:0000135	Hypogonadism
HP:0000233	Thin vermilion border
HP:0000239	Large fontanelles
HP:0000252	Microcephaly
HP:0000253	Progressive microcephaly
HP:0000316	Hypertelorism