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transmembrane protein 59

Summary

Gene Symbol

Tmem59

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

56374

KEGG Gene ID

PubChem

56374

Alliance of Genome Resources

MGI:1929278

Annotation

Keyword

Autophagy
Cell membrane
Direct protein sequencing
Endosome
Glycoprotein
Golgi apparatus
Lysosome
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9QY73	Thymic dendritic cell-derived factor 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
autophagy
glycoprotein biosynthetic process	ISO
positive regulation of autophagy	ISS
positive regulation of autophagy	ISO
positive regulation of autophagy	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

autophagy

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

process utilizing autophagic mechanism [inference]

autophagy

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of cellular process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy

regulation of autophagy [inference]

positive regulation of autophagy

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy

negative regulation of cellular process [inference]

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
Golgi cis cisterna	ISO
Golgi cis cisterna	IEA
Golgi trans cisterna	ISO
Golgi trans cisterna	IEA
Golgi membrane	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

late endosome membrane

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi cisterna [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

Displaying 1 entry
GO Term	Evidence Code	PMID
endopeptidase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	9528	HGNC:1239

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Last updated: April 6, 2026

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