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legumain

Summary

Gene Symbol

LGMN

Organism

Homo sapiens (human)

External Links

NCBI Gene

5641

KEGG Gene ID

PubChem

5641

Alliance of Genome Resources

HGNC:9472

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disulfide bond
Glycoprotein
Lysosome
Proteomics identification
Reference proteome
Signal
Thiol protease
Zymogen

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q53XC6	Asparaginyl endopeptidase Protease, cysteine 1
Q99538	Asparaginyl endopeptidase Protease, cysteine 1
Q96CY7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 40 in total

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GO Term	Evidence Code	PMID
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
renal system process	ISS
renal system process	IEA
proteolysis	ISS
proteolysis	IEA

GO Hierarchy

biological process

immune system process [inference]

antigen processing and presentation [inference]

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous peptide antigen via MHC class I [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of peptide antigen via MHC class I [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class I [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous peptide antigen via MHC class I [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

vacuolar protein processing

protein catabolic process

protein maturation

protein processing [inference]

vacuolar protein processing

receptor metabolic process [inference]

receptor catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

vitamin D metabolic process

protein metabolic process [inference]

proteolysis

protein processing [inference]

vacuolar protein processing

protein catabolic process

protein maturation

protein processing [inference]

vacuolar protein processing

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to amyloid-beta

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection organization [inference]

dendritic spine organization

postsynapse organization [inference]

dendritic spine organization

multicellular organismal process [inference]

system process [inference]

renal system process

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning

memory

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning

memory

response to stimulus [inference]

response to abiotic stimulus [inference]

response to pH [inference]

response to acidic pH

response to endogenous stimulus [inference]

response to growth factor [inference]

response to hepatocyte growth factor [inference]

cellular response to hepatocyte growth factor stimulus

cellular response to growth factor stimulus [inference]

cellular response to hepatocyte growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to hepatocyte growth factor stimulus

response to chemical [inference]

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to amyloid-beta

response to nitrogen compound [inference]

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

response to oxygen-containing compound [inference]

cellular response to oxygen-containing compound [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to amyloid-beta

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

regulation of ERBB signaling pathway [inference]

negative regulation of ERBB signaling pathway

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation [inference]

positive regulation of long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

regulation of growth [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of endothelial cell chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of endothelial cell chemotaxis

regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of endothelial cell chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of endothelial cell chemotaxis

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of multicellular organismal process [inference]

negative regulation of multicellular organism growth

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

regulation of ERBB signaling pathway [inference]

negative regulation of ERBB signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of endothelial cell chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of endothelial cell chemotaxis

regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of endothelial cell chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

regulation of ERBB signaling pathway [inference]

negative regulation of ERBB signaling pathway

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation [inference]

positive regulation of long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

regulation of multicellular organismal process [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of multicellular organismal process [inference]

negative regulation of multicellular organism growth

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation [inference]

positive regulation of long-term synaptic potentiation

Displaying entries **6 - 10** of 16 in total

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GO Term	Evidence Code	PMID
lysosome	TAS
lysosome	IEA
late endosome	TAS
late endosome	IEA
endolysosome lumen	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

endolysosome lumen

endosome lumen [inference]

endolysosome lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
cysteine-type endopeptidase activity	ISS
cysteine-type endopeptidase activity	EXP
cysteine-type endopeptidase activity	TAS
cysteine-type endopeptidase activity	IDA
cysteine-type endopeptidase activity	IMP