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MIRAGE

1-acylglycerol-3-phosphate O-acyltransferase 3

Summary

Gene Symbol

AGPAT3

Aliases

1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
LPAAT-gamma
LPAAT3
LPLAT3
lysophosphatidic acid acyltransferase gamma
lysophospholipid acyltransferase 3

Organism

Homo sapiens (human)

External Links

NCBI Gene

56894

HGNC

326

KEGG Gene ID

hsa:56894

PubChem

56894

Alliance of Genome Resources

HGNC:326

Annotation

Keyword

Acyltransferase
Alternative splicing
Endoplasmic reticulum
Nucleus
Phospholipid biosynthesis
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NRZ7	1-acylglycerol-3-phosphate O-acyltransferase 3 Lysophosphatidic acid acyltransferase gamma

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
phosphatidic acid biosynthetic process	TAS
phospholipid biosynthetic process	NAS	15367102
CDP-diacylglycerol biosynthetic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

Displaying entries **1 - 5** of 9 in total

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2

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
nuclear envelope	IDA	21173190
endoplasmic reticulum	IBA
endoplasmic reticulum	HDA	16780588
endoplasmic reticulum membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

endomembrane system

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

Golgi membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
1-acylglycerol-3-phosphate O-acyltransferase activity	NAS	15367102
1-acylglycerol-3-phosphate O-acyltransferase activity	TAS
1-acylglycerol-3-phosphate O-acyltransferase activity	IDA	21173190
1-acylglycerol-3-phosphate O-acyltransferase activity	IBA
protein binding	IPI	32296183

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity [inference]

acylglycerol O-acyltransferase activity [inference]

1-acylglycerol-3-phosphate O-acyltransferase activity

lysophospholipid acyltransferase activity [inference]

lysophosphatidic acid acyltransferase activity [inference]

1-acylglycerol-3-phosphate O-acyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 3

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
transferase activity

Displaying **all 2** entries
InterPro
Acyltransferase, C-terminal domain
Phospholipid/glycerol acyltransferase

KEGG BRITE Database

Orthology

K13523

Name

lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase [EC:2.3.1.51 2.3.1.-]

References

Rhea

a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA

CoA + a 1,2-diacyl-sn-glycero-3-phosphate

Enzyme

2.3.1.51

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002540
Gene Name: 1-acylglycerol-3-phosphate O-acyltransferase 3

Ortholog

Displaying entries **61 - 70** of 90 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Salmo salar	106582438		SALSA79431
Equus asinus asinus	106824447		EQUAS30662
Sinocyclocheilus grahami	107560981		SINGR84548
Cebus imitator	108311196		CEBIM16877
Rhinopithecus bieti	108539817		RHIBE20235
Crocodylus porosus	109305877		CROPO03799
Phascolarctos cinereus	110199138		PHACI13022
Vulpes vulpes	112909541		VULVU35618
Pseudonaja textilis	113444752		PSETE17512
Athene cunicularia	113478176		ATHCN03306

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.3.0

Last updated: August 4, 2025