GlyCosmos Portal

Submissions

zinc finger NFX1-type containing 1

Summary

Gene Symbol

ZNFX1

Organism

Homo sapiens (human)

External Links

NCBI Gene

57169

PubChem

57169

Alliance of Genome Resources

HGNC:29271

JoGo

ZNFX1

TogoVar

ZNFX1

Annotation

Keyword

3D-structure
Alternative splicing
Antiviral defense
Coiled coil
Cytoplasm
Disease variant
Innate immunity
Mitochondrion outer membrane
Proteomics identification
RNA-binding
Reference proteome
Repeat
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9P2E3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
activation of innate immune response	ISS	http://purl.obolibrary.org/obo/go/references/0000024
activation of innate immune response	IEA	http://purl.obolibrary.org/obo/go/references/0000107
regulatory ncRNA-mediated heterochromatin formation	IBA	http://purl.obolibrary.org/obo/go/references/0000033
defense response to bacterium	IMP	33876776
negative regulation of viral genome replication	ISS	http://purl.obolibrary.org/obo/go/references/0000024

GO Hierarchy

biological process

immune system process [inference]

activation of immune response [inference]

activation of innate immune response

immune response [inference]

innate immune response

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation

heterochromatin organization [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation

cellular component assembly [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of NLRP3 inflammasome complex assembly

negative regulation of viral process [inference]

negative regulation of viral genome replication

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of viral process [inference]

negative regulation of viral process [inference]

negative regulation of viral genome replication

regulation of viral life cycle [inference]

regulation of viral genome replication [inference]

negative regulation of viral genome replication

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of NLRP3 inflammasome complex assembly

regulation of NLRP3 inflammasome complex assembly [inference]

negative regulation of NLRP3 inflammasome complex assembly

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of NLRP3 inflammasome complex assembly

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of NLRP3 inflammasome complex assembly

regulation of NLRP3 inflammasome complex assembly [inference]

negative regulation of NLRP3 inflammasome complex assembly

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of NLRP3 inflammasome complex assembly

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
nucleus	IEA
cytoplasm	IEA
mitochondrial outer membrane	ISS	http://purl.obolibrary.org/obo/go/references/0000024
mitochondrial outer membrane	IEA	http://purl.obolibrary.org/obo/go/references/0000044 http://purl.obolibrary.org/obo/go/references/0000107
cytosol	IDA	39333773

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

nuclear RNA-directed RNA polymerase complex

intracellular protein-containing complex [inference]

RNA polymerase complex [inference]

RNA-directed RNA polymerase complex [inference]

nuclear RNA-directed RNA polymerase complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

RNA polymerase complex [inference]

RNA-directed RNA polymerase complex [inference]

nuclear RNA-directed RNA polymerase complex

cellular anatomical structure [inference]

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
RNA binding	IBA
RNA binding	IEA	http://purl.obolibrary.org/obo/go/references/0000107
RNA binding	HDA	22658674 22681889
helicase activity	IEA	http://purl.obolibrary.org/obo/go/references/0000002
zinc ion binding	IEA	http://purl.obolibrary.org/obo/go/references/0000002

GO Hierarchy

molecular function

catalytic activity [inference]

isomerase activity [inference]

macromolecular conformation isomerase activity [inference]

nucleic acid conformation isomerase activity [inference]

helicase activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity

binding [inference]

nucleic acid binding [inference]

RNA binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

molecular sequestering activity [inference]

protein sequestering activity

ATP-dependent activity [inference]

helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

nfx1-type Zinc finger-containing protein 1

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
InterPro
DNA2/NAM7 helicase, helicase domain
DNA2/NAM7 helicase-like, C-terminal
DNA2/NAM7-like helicase
P-loop containing nucleoside triphosphate hydrolase
Upf1-like, C-terminal helicase domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:612	primary immunodeficiency disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements