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cannabinoid receptor 2

Summary

Gene Symbol

Cnr2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

57302

PubChem

57302

Alliance of Genome Resources

RGD:619713

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
G-protein coupled receptor
Glycoprotein
Inflammatory response
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q9QZN9
A6IT74
C6G965
C6G964

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
response to amphetamine	IEP	20067581
inflammatory response	IEA
G protein-coupled receptor signaling pathway	IDA	12084572
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
regulation of metabolic process	IBA

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

trans-synaptic signaling by lipid [inference]

trans-synaptic signaling by endocannabinoid [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

trans-synaptic signaling, modulating synaptic transmission [inference]

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

cannabinoid signaling pathway

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to lipid [inference]

response to lipopolysaccharide

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to oxygen-containing compound [inference]

response to lipopolysaccharide

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

regulation of mast cell activation [inference]

negative regulation of mast cell activation

regulation of metabolic process

regulation of signaling [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

trans-synaptic signaling, modulating synaptic transmission [inference]

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

trans-synaptic signaling by lipid [inference]

trans-synaptic signaling by endocannabinoid [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

trans-synaptic signaling, modulating synaptic transmission [inference]

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of action potential

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

cannabinoid signaling pathway

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

trans-synaptic signaling, modulating synaptic transmission [inference]

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

regulation of mast cell activation [inference]

negative regulation of mast cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

regulation of mast cell activation [inference]

negative regulation of mast cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

regulation of action potential [inference]

negative regulation of action potential

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of action potential [inference]

negative regulation of action potential

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of nitric-oxide synthase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of nitric-oxide synthase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of nitric-oxide synthase activity

regulation of nitric-oxide synthase activity [inference]

negative regulation of nitric-oxide synthase activity

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of nitric-oxide synthase activity

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
endoplasmic reticulum	ISO
plasma membrane	IBA
dendrite	IDA	18991891
extrinsic component of cytoplasmic side of plasma membrane	IDA	18798269

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of cytoplasmic side of plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

cell body [inference]

neuronal cell body

Displaying **all 3** entries
GO Term	Evidence Code	PMID
G protein-coupled receptor activity	IDA	10688601
cannabinoid receptor activity	IDA	10688601
cannabinoid receptor activity	IBA

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

cannabinoid receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cannabinoid receptor 1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cannabinoid receptor activity
cannabinoid signaling pathway

Displaying **all 3** entries
InterPro
Cannabinoid receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
extrinsic component of cytoplasmic side of plasma membrane	PMID:18798269
dendrite	PMID:18991891
neuronal cell body	PMID:18991891

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:11446	sciatic neuropathy	Alliance of Genome Resources
DOID:12858	Huntington's disease	Alliance of Genome Resources
DOID:848	arthritis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 64 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1269	Xenbase:XB-GENE-488004	HUMAN48069
Mus musculus	12802	Xenbase:XB-GENE-488004	MOUSE40979
Xenopus tropicalis	57302	Xenbase:XB-GENE-488004
Pan troglodytes	456625		PANTR20244
Bos taurus	539769		BOVIN25195
Canis lupus familiaris	612289		CANLF07027
Macaca mulatta	711155		MACMU22214
Monodelphis domestica	100010312		MONDO25024
Equus caballus	100071536		HORSE27465
Ornithorhynchus anatinus	100091779		ORNAN08414