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prostaglandin E receptor 4

Summary

Gene Symbol

PTGER4

Organism

Homo sapiens (human)

External Links

NCBI Gene

5734

PubChem

5734

Alliance of Genome Resources

HGNC:9596

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P35408	Prostanoid EP4 receptor
A0PJF5	Prostanoid EP4 receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 20** of 26 in total

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GO Term	Evidence Code	PMID
response to prostaglandin E	IDA	8163486
T-helper cell differentiation	ISS
negative regulation of inflammatory response	IDA	16424369
negative regulation of inflammatory response	IBA
positive regulation of inflammatory response	ISS

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

immune response

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell activation [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

alpha-beta T cell activation [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

CD4-positive, alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell activation [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

alpha-beta T cell activation [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

CD4-positive, alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

ERK1 and ERK2 cascade

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin E stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin E stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin E stimulus

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to prostaglandin E stimulus

cellular response to ketone [inference]

cellular response to prostaglandin E stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell activation [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

alpha-beta T cell activation [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

CD4-positive, alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

bone development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to nematode

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

immune response

response to external stimulus [inference]

response to mechanical stimulus

cellular response to mechanical stimulus

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to nematode

cellular response to external stimulus [inference]

cellular response to mechanical stimulus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to nematode

response to abiotic stimulus [inference]

response to mechanical stimulus

cellular response to mechanical stimulus

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin E stimulus

response to prostaglandin [inference]

response to prostaglandin E

cellular response to prostaglandin E stimulus

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin E stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin E stimulus

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin E stimulus

response to prostaglandin [inference]

response to prostaglandin E

cellular response to prostaglandin E stimulus

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin E stimulus

response to lipid [inference]

response to lipopolysaccharide

response to prostaglandin [inference]

response to prostaglandin E

cellular response to prostaglandin E stimulus

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin E stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin E stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin E stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin E stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin E stimulus

response to alcohol [inference]

response to prostaglandin E

cellular response to prostaglandin E stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin E stimulus

response to ketone [inference]

response to prostaglandin E

cellular response to prostaglandin E stimulus

cellular response to ketone [inference]

cellular response to prostaglandin E stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin E stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin E stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin E stimulus

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to prostaglandin E stimulus

cellular response to ketone [inference]

cellular response to prostaglandin E stimulus

response to oxygen-containing compound [inference]

response to lipopolysaccharide

response to alcohol [inference]

response to prostaglandin E

cellular response to prostaglandin E stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin E stimulus

response to ketone [inference]

response to prostaglandin E

cellular response to prostaglandin E stimulus

cellular response to ketone [inference]

cellular response to prostaglandin E stimulus

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to prostaglandin E stimulus

cellular response to ketone [inference]

cellular response to prostaglandin E stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin E stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin E stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin E stimulus

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to prostaglandin E stimulus

cellular response to ketone [inference]

cellular response to prostaglandin E stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of eosinophil extravasation

negative regulation of eosinophil migration [inference]

negative regulation of eosinophil extravasation

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of eosinophil extravasation

negative regulation of eosinophil migration [inference]

negative regulation of eosinophil extravasation

regulation of cellular extravasation [inference]

negative regulation of cellular extravasation [inference]

negative regulation of eosinophil extravasation

regulation of eosinophil extravasation [inference]

negative regulation of eosinophil extravasation

regulation of eosinophil migration [inference]

negative regulation of eosinophil migration [inference]

negative regulation of eosinophil extravasation

regulation of eosinophil extravasation [inference]

negative regulation of eosinophil extravasation

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

negative regulation of gene expression [inference]

negative regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

negative regulation of gene expression [inference]

negative regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

negative regulation of gene expression [inference]

negative regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of eosinophil extravasation

negative regulation of eosinophil migration [inference]

negative regulation of eosinophil extravasation

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of eosinophil extravasation

negative regulation of eosinophil migration [inference]

negative regulation of eosinophil extravasation

regulation of cellular extravasation [inference]

negative regulation of cellular extravasation [inference]

negative regulation of eosinophil extravasation

regulation of eosinophil extravasation [inference]

negative regulation of eosinophil extravasation

regulation of eosinophil migration [inference]

negative regulation of eosinophil migration [inference]

negative regulation of eosinophil extravasation

regulation of eosinophil extravasation [inference]

negative regulation of eosinophil extravasation

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of eosinophil extravasation

negative regulation of eosinophil migration [inference]

negative regulation of eosinophil extravasation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of eosinophil extravasation

negative regulation of eosinophil migration [inference]

negative regulation of eosinophil extravasation

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of eosinophil extravasation

negative regulation of eosinophil migration [inference]

negative regulation of eosinophil extravasation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of eosinophil extravasation

negative regulation of eosinophil migration [inference]

negative regulation of eosinophil extravasation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of integrin activation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of eosinophil extravasation

negative regulation of eosinophil migration [inference]

negative regulation of eosinophil extravasation

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

positive regulation of defense response [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

ERK1 and ERK2 cascade

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

negative regulation of gene expression [inference]

negative regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

regulation of stress fiber assembly

regulation of cellular component biogenesis [inference]

regulation of actin filament bundle assembly [inference]

regulation of stress fiber assembly

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of integrin activation

regulation of integrin activation [inference]

negative regulation of integrin activation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of integrin activation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of eosinophil extravasation

negative regulation of eosinophil migration [inference]

negative regulation of eosinophil extravasation

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

regulation of stress fiber assembly

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of integrin activation

regulation of integrin activation [inference]

negative regulation of integrin activation

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of integrin activation

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

regulation of stress fiber assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of eosinophil extravasation

negative regulation of eosinophil migration [inference]

negative regulation of eosinophil extravasation

regulation of cellular extravasation [inference]

negative regulation of cellular extravasation [inference]

negative regulation of eosinophil extravasation

regulation of eosinophil extravasation [inference]

negative regulation of eosinophil extravasation

regulation of eosinophil migration [inference]

negative regulation of eosinophil migration [inference]

negative regulation of eosinophil extravasation

regulation of eosinophil extravasation [inference]

negative regulation of eosinophil extravasation

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of eosinophil extravasation

negative regulation of eosinophil migration [inference]

negative regulation of eosinophil extravasation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of cellular extravasation [inference]

negative regulation of eosinophil extravasation

negative regulation of eosinophil migration [inference]

negative regulation of eosinophil extravasation

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of ossification

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	16424369 8163486
plasma membrane	IBA
membrane	NAS	8163486

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
prostaglandin E receptor activity	IDA	8078484 8163486
prostaglandin E receptor activity	IBA
protein binding	IPI	16424369

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

icosanoid receptor activity [inference]

prostanoid receptor activity [inference]

prostaglandin receptor activity [inference]

prostaglandin E receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

prostaglandin e2 receptor ep3 subtype

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
inflammatory response
positive regulation of cytosolic calcium ion concentration

Displaying **all 3** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Prostanoid receptor

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:2349	arteriosclerosis	Alliance of Genome Resources
DOID:7147	ankylosing spondylitis	Alliance of Genome Resources
DOID:8577	ulcerative colitis	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of 90 in total

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Species	Gene ID	Orthologous MAtrix
Mustela putorius furo	101670371	MUSPF19850
Ficedula albicollis	101810084	FICAL08954
Macaca fascicularis	101865027	MACFA35386
Melopsittacus undulatus	101869553	MELUD04159
Chrysemys picta bellii	101941886	CHRPI07809
Ictidomys tridecemlineatus	101957716	ICTTR02852
Chinchilla lanigera	102024139	CHILA08135
Capra hircus	102188631	CAPHI13171
Latimeria chalumnae	102361246	LATCH01047
Myotis lucifugus	102437889	MYOLU05897

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements