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prostaglandin I2 receptor

Summary

Gene Symbol

PTGIR

Organism

Homo sapiens (human)

External Links

NCBI Gene

5739

PubChem

5739

Alliance of Genome Resources

HGNC:9602

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Methylation
Prenylation
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P43119	Prostaglandin I2 receptor Prostanoid IP receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
inflammatory response	IBA
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	7512962
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	20622039
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
positive regulation of cytosolic calcium ion concentration	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway

regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway

signaling [inference]

cell-cell signaling

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway

regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway

regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

negative regulation of smooth muscle cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytosol	IDA	20622039
plasma membrane	TAS
plasma membrane	IDA	20622039
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	TAS
prostacyclin receptor activity	IBA

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

icosanoid receptor activity [inference]

prostanoid receptor activity [inference]

prostaglandin receptor activity [inference]

prostacyclin receptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

prostaglandin e2 receptor ep3 subtype

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
inflammatory response
positive regulation of cytosolic calcium ion concentration

Displaying **all 3** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Prostanoid receptor

Ortholog

Displaying entries **11 - 20** of 96 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	19217	FB:FBgn0036742
Drosophila melanogaster	19219	FB:FBgn0036742
Drosophila melanogaster	19220	FB:FBgn0036742
Mus musculus	19222	Xenbase:XB-GENE-982059	MOUSE52641
Drosophila melanogaster	24816	FB:FBgn0036742
Drosophila melanogaster	24929	FB:FBgn0036742
Drosophila melanogaster	25637	FB:FBgn0036742
Drosophila melanogaster	25652	FB:FBgn0036742
Drosophila melanogaster	63889	FB:FBgn0036742
Drosophila melanogaster	81752	FB:FBgn0036742