GlyCosmos Portal

Annotation

Keyword

3D-structure
Acetylation
Dioxygenase
Disulfide bond
Glycoprotein
Heme
Membrane
Microsome
Nucleus
Peroxidase
Prostaglandin biosynthesis
Proteomics identification
Reference proteome
S-nitrosylation
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P35354	Cyclooxygenase-2 PHS II Prostaglandin H2 synthase 2 Prostaglandin-endoperoxide synthase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 39 in total

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GO Term	Evidence Code	PMID
prostaglandin biosynthetic process	ISS
prostaglandin biosynthetic process	NAS
prostaglandin biosynthetic process	IDA
prostaglandin biosynthetic process	IEA
response to oxidative stress	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process

prostaglandin biosynthetic process

long-chain fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process

prostaglandin biosynthetic process

long-chain fatty acid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonate metabolic process [inference]

cyclooxygenase pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process

prostaglandin biosynthetic process

long-chain fatty acid biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process

prostaglandin biosynthetic process

prostanoid metabolic process [inference]

prostaglandin metabolic process [inference]

prostaglandin biosynthetic process

prostanoid biosynthetic process

prostaglandin biosynthetic process

arachidonate metabolic process [inference]

cyclooxygenase pathway

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process

prostaglandin biosynthetic process

long-chain fatty acid biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process

prostaglandin biosynthetic process

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process [inference]

prostaglandin biosynthetic process

prostanoid biosynthetic process

prostaglandin biosynthetic process

arachidonate metabolic process [inference]

cyclooxygenase pathway

lipoxygenase pathway

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process

prostaglandin biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonate metabolic process [inference]

cyclooxygenase pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process

prostaglandin biosynthetic process

long-chain fatty acid biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process

prostaglandin biosynthetic process

prostanoid metabolic process [inference]

prostaglandin metabolic process [inference]

prostaglandin biosynthetic process

prostanoid biosynthetic process

prostaglandin biosynthetic process

arachidonate metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process

prostaglandin biosynthetic process

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process

prostaglandin biosynthetic process

long-chain fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process

prostaglandin biosynthetic process

long-chain fatty acid biosynthetic process

olefinic compound metabolic process [inference]

arachidonate metabolic process [inference]

cyclooxygenase pathway

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to non-ionic osmotic stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to non-ionic osmotic stress

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

cellular response to non-ionic osmotic stress

export from cell [inference]

secretion by cell [inference]

signal release [inference]

prostaglandin secretion

lipid export from cell [inference]

prostaglandin secretion

cellular detoxification [inference]

cellular oxidant detoxification

reproductive process [inference]

developmental process involved in reproduction [inference]

decidualization

embryo implantation

developmental process [inference]

developmental process involved in reproduction [inference]

decidualization

anatomical structure development [inference]

tissue development [inference]

decidualization

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to nematode

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

cellular response to hypoxia

response to osmotic stress [inference]

response to non-ionic osmotic stress [inference]

cellular response to non-ionic osmotic stress

cellular response to osmotic stress [inference]

cellular response to non-ionic osmotic stress

response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to non-ionic osmotic stress

response to fluid shear stress [inference]

cellular response to fluid shear stress

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to nematode

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to nematode

response to abiotic stimulus [inference]

response to osmotic stress [inference]

response to non-ionic osmotic stress [inference]

cellular response to non-ionic osmotic stress

cellular response to osmotic stress [inference]

cellular response to non-ionic osmotic stress

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

cellular response to non-ionic osmotic stress

response to chemical [inference]

response to selenium ion

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to non-ionic osmotic stress

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to non-ionic osmotic stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to non-ionic osmotic stress

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

cellular response to non-ionic osmotic stress

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

fatty acid transport [inference]

prostaglandin transport [inference]

prostaglandin secretion

lipid export from cell [inference]

prostaglandin secretion

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

prostaglandin transport [inference]

prostaglandin secretion

icosanoid transport [inference]

prostaglandin transport [inference]

prostaglandin secretion

icosanoid secretion [inference]

prostaglandin secretion

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

prostaglandin transport [inference]

prostaglandin secretion

icosanoid transport [inference]

prostaglandin transport [inference]

prostaglandin secretion

icosanoid secretion [inference]

prostaglandin secretion

secretion [inference]

icosanoid secretion [inference]

prostaglandin secretion

secretion by cell [inference]

signal release [inference]

prostaglandin secretion

export from cell [inference]

secretion by cell [inference]

signal release [inference]

prostaglandin secretion

lipid export from cell [inference]

prostaglandin secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

regulation of blood vessel endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

regulation of cell migration involved in sprouting angiogenesis [inference]

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation [inference]

positive regulation of brown fat cell differentiation

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of fever generation

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of fever generation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation [inference]

positive regulation of brown fat cell differentiation

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of heat generation [inference]

positive regulation of fever generation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of fever generation

regulation of inflammatory response

regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of fever generation

regulation of fever generation [inference]

positive regulation of fever generation

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of fever generation

regulation of neuroinflammatory response

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of fever generation

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of fever generation

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of fever generation

regulation of inflammatory response

regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of fever generation

regulation of fever generation [inference]

positive regulation of fever generation

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of fever generation

regulation of neuroinflammatory response

regulation of response to osmotic stress [inference]

regulation of cellular response to osmotic stress [inference]

regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of cellular response to stress [inference]

regulation of cellular response to osmotic stress [inference]

regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation [inference]

positive regulation of brown fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation [inference]

positive regulation of brown fat cell differentiation

regulation of brown fat cell differentiation [inference]

positive regulation of brown fat cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation [inference]

positive regulation of brown fat cell differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta production

regulation of fibroblast growth factor production [inference]

positive regulation of fibroblast growth factor production

regulation of platelet-derived growth factor production [inference]

positive regulation of platelet-derived growth factor production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

regulation of unsaturated fatty acid biosynthetic process [inference]

regulation of prostaglandin biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

regulation of ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

regulation of unsaturated fatty acid biosynthetic process [inference]

regulation of prostaglandin biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta production

regulation of fibroblast growth factor production [inference]

positive regulation of fibroblast growth factor production

regulation of platelet-derived growth factor production [inference]

positive regulation of platelet-derived growth factor production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of small molecule metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

regulation of unsaturated fatty acid biosynthetic process [inference]

regulation of prostaglandin biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

regulation of unsaturated fatty acid biosynthetic process [inference]

regulation of prostaglandin biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

regulation of unsaturated fatty acid biosynthetic process [inference]

regulation of prostaglandin biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation [inference]

positive regulation of brown fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation [inference]

positive regulation of brown fat cell differentiation

regulation of brown fat cell differentiation [inference]

positive regulation of brown fat cell differentiation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process [inference]

positive regulation of unsaturated fatty acid biosynthetic process [inference]

positive regulation of prostaglandin biosynthetic process

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation [inference]

positive regulation of brown fat cell differentiation

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of cellular response to stress [inference]

regulation of cellular response to osmotic stress [inference]

regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [inference]

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

regulation of blood vessel endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

regulation of cell migration involved in sprouting angiogenesis [inference]

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration [inference]

positive regulation of cell migration involved in sprouting angiogenesis

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta production

regulation of fibroblast growth factor production [inference]

positive regulation of fibroblast growth factor production

regulation of platelet-derived growth factor production [inference]

positive regulation of platelet-derived growth factor production

regulation of heat generation [inference]

regulation of fever generation [inference]

positive regulation of fever generation

positive regulation of heat generation [inference]

positive regulation of fever generation

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of heat generation [inference]

positive regulation of fever generation

regulation of biological quality [inference]

regulation of blood pressure

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
nuclear inner membrane	IDA
nuclear inner membrane	IEA
nuclear outer membrane	IDA
nuclear outer membrane	IEA
cytoplasm	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

nuclear outer membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle inner membrane [inference]

nuclear inner membrane

nuclear membrane [inference]

bounding membrane of organelle [inference]

organelle outer membrane [inference]

nuclear outer membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
peroxidase activity	NAS
peroxidase activity	IEA
prostaglandin-endoperoxide synthase activity	EXP
prostaglandin-endoperoxide synthase activity	IDA
prostaglandin-endoperoxide synthase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

prostaglandin-endoperoxide synthase activity

dioxygenase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

binding [inference]

protein binding

enzyme binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peroxidase

Functional Category

Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 4** entries
Gene Ontology
cellular oxidant detoxification
heme binding
metal ion binding
response to oxidative stress

Displaying **all 3** entries
InterPro
Haem peroxidase domain superfamily, animal type
Haem peroxidase superfamily
Haem peroxidase, animal-type

Human Protein Atlas

ENSG00000073756

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K11987

Name

prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]

References

Rhea

RHEA:23728

O₂ + AH₂ + (5Z,8Z,11Z,14Z)-eicosatetraenoate

A + H₂O + prostaglandin H₂

Enzyme

1.14.99.1

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 19 in total

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DO ID	Disease Name	Source
DOID:0050156	idiopathic pulmonary fibrosis	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:11335	sarcoidosis	Alliance of Genome Resources
DOID:11963	esophagitis	Alliance of Genome Resources
DOID:1287	cardiovascular system disease	Alliance of Genome Resources
DOID:1485	cystic fibrosis	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:2349	arteriosclerosis	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

PubChem Disease

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000761
Gene Name: prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements