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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

solute carrier family 12 member 5

Summary

Gene Symbol

SLC12A5

Organism

Homo sapiens (human)

External Links

NCBI Gene

57468

KEGG Gene ID

PubChem

57468

Alliance of Genome Resources

HGNC:13818

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cell projection
Chloride
Disease variant
Disulfide bond
Epilepsy
Glycoprotein
Metal-binding
Phosphoprotein
Potassium transport
Proteomics identification
Reference proteome
Symport
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H2X9	Electroneutral potassium-chloride cotransporter 2 K-Cl cotransporter 2 Neuronal K-Cl cotransporter

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
ion transport	IDA
monoatomic ion transport	IDA
monoatomic ion transport	IEA
ion transport	IEA
potassium ion transport	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cellular localization [inference]

localization within membrane [inference]

receptor diffusion trapping [inference]

neurotransmitter receptor diffusion trapping [inference]

postsynaptic neurotransmitter receptor diffusion trapping

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

ammonium transmembrane transport

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

behavior [inference]

learning or memory [inference]

learning

thermosensory behavior

multicellular organism growth

developmental process

anatomical structure development [inference]

dendritic spine development

growth [inference]

developmental growth [inference]

multicellular organism growth

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

potassium ion homeostasis

monoatomic anion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

chloride ion homeostasis

intracellular chloride ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

inorganic ion homeostasis [inference]

chloride ion homeostasis

intracellular chloride ion homeostasis

potassium ion homeostasis

response to stimulus [inference]

response to stress [inference]

response to osmotic stress [inference]

hypotonic response

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hypotonic response

response to temperature stimulus [inference]

thermosensory behavior

response to chemical [inference]

response to xenobiotic stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transport [inference]

chloride transport

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport

chloride transmembrane transport

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

ammonium transmembrane transport

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

nitrogen compound transport [inference]

ammonium transmembrane transport

import into cell [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

cellular localization [inference]

localization within membrane [inference]

receptor diffusion trapping [inference]

neurotransmitter receptor diffusion trapping [inference]

postsynaptic neurotransmitter receptor diffusion trapping

receptor localization to synapse [inference]

postsynaptic neurotransmitter receptor diffusion trapping

biological regulation [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of biological quality [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

postsynaptic neurotransmitter receptor diffusion trapping

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IEA
membrane	IDA
membrane	IEA
apical plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

neuron projection membrane [inference]

dendrite membrane

synaptic membrane [inference]

postsynaptic specialization membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

leading edge membrane [inference]

neuron projection membrane [inference]

dendrite membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

perikaryon

cell body [inference]

neuronal cell body

cell periphery

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
ammonium channel activity	IEA
chloride transmembrane transporter activity	IDA
chloride:monoatomic cation symporter activity	IEA
potassium:chloride symporter activity	TAS
potassium:chloride symporter activity	IDA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

chloride:monoatomic cation symporter activity

potassium:chloride symporter activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium:chloride symporter activity

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity

chloride:monoatomic cation symporter activity

potassium:chloride symporter activity

monoatomic anion:monoatomic cation symporter activity [inference]

chloride:monoatomic cation symporter activity

potassium:chloride symporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

ammonium channel activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

chloride:monoatomic cation symporter activity

potassium:chloride symporter activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080460	developmental and epileptic encephalopathy 34	Alliance of Genome Resources
DOID:0111315	obsolete idiopathic generalized epilepsy 14	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	57138	MGI:1862037
Rattus norvegicus	171373	RGD:620811

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026