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ring finger protein 213

Summary

Gene Symbol

RNF213

Aliases

ALK lymphoma oligomerization partner on chromosome 17
ALO17
KIAA1554
NET57
mysterin

Organism

Homo sapiens (human)

External Links

NCBI Gene

57674

HGNC

14539

KEGG Gene ID

[""]

PubChem

57674

Alliance of Genome Resources

HGNC:14539

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Angiogenesis
Chromosomal rearrangement
Coiled coil
Cytoplasm
Disease variant
Hydrolase
Immunity
Isopeptide bond
Lipid droplet
Lipid metabolism
Multifunctional enzyme
Phosphoprotein
Proteomics identification
Proto-oncogene
Reference proteome
Transferase
Ubl conjugation
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A0A0MTR7	E3 ubiquitin-lipopolysaccharide ligase RNF213 Mysterin RING finger protein 213
A0A0A0MTC1	E3 ubiquitin-lipopolysaccharide ligase RNF213 Mysterin RING finger protein 213
Q63HN8	ALK lymphoma oligomerization partner on chromosome 17 E3 ubiquitin-lipopolysaccharide ligase RNF213 Mysterin RING finger protein 213

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
angiogenesis	IMP
angiogenesis	IEA
sprouting angiogenesis	IMP
sprouting angiogenesis	IBA
immune system process

GO Hierarchy

biological process

immune system process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

autophagy [inference]

macroautophagy [inference]

xenophagy

macromolecule catabolic process [inference]

protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K63-linked ubiquitination

protein autoubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K63-linked ubiquitination

protein autoubiquitination

primary metabolic process [inference]

lipid metabolic process [inference]

lipid modification [inference]

lipid modification by small protein conjugation [inference]

lipid ubiquitination

protein metabolic process [inference]

protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K63-linked ubiquitination

protein autoubiquitination

process utilizing autophagic mechanism [inference]

autophagy [inference]

macroautophagy [inference]

xenophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

lipid droplet organization [inference]

lipid droplet formation

organelle assembly [inference]

membraneless organelle assembly [inference]

lipid droplet formation

cellular component assembly [inference]

organelle assembly [inference]

membraneless organelle assembly [inference]

lipid droplet formation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

sprouting angiogenesis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to bacterium

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of non-canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of non-canonical Wnt signaling pathway

regulation of non-canonical Wnt signaling pathway [inference]

negative regulation of non-canonical Wnt signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of non-canonical Wnt signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of non-canonical Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of non-canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of non-canonical Wnt signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of non-canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of non-canonical Wnt signaling pathway

regulation of non-canonical Wnt signaling pathway [inference]

negative regulation of non-canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of non-canonical Wnt signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of non-canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of non-canonical Wnt signaling pathway

regulation of non-canonical Wnt signaling pathway [inference]

negative regulation of non-canonical Wnt signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of non-canonical Wnt signaling pathway

regulation of metabolic process [inference]

regulation of primary metabolic process [inference]

regulation of lipid metabolic process

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of non-canonical Wnt signaling pathway

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleolus
cytoplasm	IDA
lipid droplet	IDA
lipid droplet	IEA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

intracellular organelle [inference]

intracellular membraneless organelle [inference]

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
ubiquitin-protein transferase activity	TAS
ubiquitin-protein transferase activity	IDA
ubiquitin-protein transferase activity	IBA
ubiquitin-protein transferase activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

E3 ubiquitin-protein ligase

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
metal ion binding

Displaying **all 3** entries
InterPro
AAA+ ATPase domain
E3 ubiquitin-protein ligase RNF213
P-loop containing nucleoside triphosphate hydrolase

Human Protein Atlas

ENSG00000173821

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:13099	Moyamoya disease	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying **all 9** entries
HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0001009	Telangiectasia
HP:0001249	Intellectual disability
HP:0001250	Seizure
HP:0002119	Ventriculomegaly
HP:0002326	Transient ischemic attack
HP:0011834	Moyamoya phenomenon
HP:0100659	Abnormal cerebral vascular morphology