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MIRAGE

angiopoietin-like 4

Summary

Gene Symbol

Angptl4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

57875

KEGG Gene ID

[""]

PubChem

57875

Alliance of Genome Resources

MGI:1888999

Annotation

Keyword

Angiogenesis
Coiled coil
Disulfide bond
Extracellular matrix
Glycoprotein
Lipid metabolism
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Z1P8	425O18-1 Angiopoietin-like protein 4 Fasting-induced adipose factor Hepatic fibrinogen/angiopoietin-related protein Secreted protein Bk89

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
angiogenesis
response to hypoxia	IEA
lipid metabolic process
blood coagulation	IEA
cellular response to starvation	NAS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

protein unfolding

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis

response to stimulus [inference]

response to stress [inference]

response to hypoxia

cellular response to stress [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

regulation of acylglycerol transport [inference]

regulation of triglyceride transport

regulation of lipid localization [inference]

regulation of lipid transport [inference]

regulation of acylglycerol transport [inference]

regulation of triglyceride transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of lipid metabolic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of endothelial cell apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of very-low-density lipoprotein particle remodeling

negative regulation of multicellular organismal process [inference]

negative regulation of very-low-density lipoprotein particle remodeling

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of lipid metabolic process

regulation of ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

positive regulation of lipid metabolic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of endothelial cell apoptotic process

regulation of endothelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of endothelial cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of lipid metabolic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of endothelial cell apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of very-low-density lipoprotein particle remodeling

regulation of cellular component organization [inference]

regulation of very-low-density lipoprotein particle remodeling [inference]

negative regulation of very-low-density lipoprotein particle remodeling

negative regulation of cellular component organization [inference]

negative regulation of very-low-density lipoprotein particle remodeling

regulation of chylomicron remodeling

regulation of multicellular organismal process [inference]

regulation of very-low-density lipoprotein particle remodeling [inference]

negative regulation of very-low-density lipoprotein particle remodeling

negative regulation of multicellular organismal process [inference]

negative regulation of very-low-density lipoprotein particle remodeling

regulation of chylomicron remodeling

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular region	EXP
extracellular region	TAS
extracellular region	IDA
extracellular region	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
enzyme inhibitor activity	IDA
lipase binding	ISO
lipase binding	IEA
identical protein binding	ISO
identical protein binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

lipase binding

identical protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity

lipase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity

lipase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Angiopoietin-related protein 4

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
lipid metabolic process
triglyceride homeostasis

Displaying **all 4** entries
InterPro
Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Fibrinogen, conserved site
Fibrinogen-like, C-terminal

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026