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Guidelines

MIRAGE

pentraxin 3

Summary

Gene Symbol

PTX3

Organism

Homo sapiens (human)

External Links

NCBI Gene

5806

PubChem

5806

Alliance of Genome Resources

HGNC:9692

JoGo

PTX3

TogoVar

PTX3

Annotation

Keyword

3D-structure
Coiled coil
Disulfide bond
Glycoprotein
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P26022	Pentaxin-related protein PTX3 Tumor necrosis factor alpha-induced protein 5 Tumor necrosis factor-inducible gene 14 protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
ovarian cumulus expansion
response to yeast
immune system process	IEA
inflammatory response	TAS
immune response	IEA

GO Hierarchy

biological process

immune system process

immune effector process [inference]

opsonization

immune response

innate immune response

host-mediated suppression of symbiont invasion

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

reproductive process [inference]

ovulation cycle process [inference]

ovarian cumulus expansion

growth [inference]

developmental growth [inference]

ovarian cumulus expansion

biological process involved in interspecies interaction between organisms [inference]

modulation of process of another organism [inference]

host-mediated perturbation of symbiont process [inference]

host-mediated perturbation of viral process [inference]

host-mediated suppression of viral proces

negative regulation by host of viral glycoprotein metabolic process

modulation by host of viral glycoprotein metabolic process [inference]

negative regulation by host of viral glycoprotein metabolic process

host-mediated suppression of symbiont invasion

response to other organism

response to fungus [inference]

response to yeast

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

host-mediated suppression of symbiont invasion

rhythmic process [inference]

ovulation cycle process [inference]

ovarian cumulus expansion

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

host-mediated suppression of symbiont invasion

immune response

innate immune response

host-mediated suppression of symbiont invasion

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism

response to fungus [inference]

response to yeast

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

host-mediated suppression of symbiont invasion

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism

response to fungus [inference]

response to yeast

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

host-mediated suppression of symbiont invasion

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

negative regulation of viral process [inference]

negative regulation by host of viral glycoprotein metabolic process

regulation of viral process [inference]

negative regulation of viral process [inference]

negative regulation by host of viral glycoprotein metabolic process

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	IDA
extracellular region	IBA
extracellular region	IEA
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

tertiary granule lumen

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
complement component C1q complex binding	IDA
complement component C1q complex binding	IBA
(1->3)-beta-D-glucan binding	IEA
protein binding	IPI
identical protein binding	IPI

GO Hierarchy

molecular function

binding [inference]

protein binding

opsonin binding [inference]

complement component C1q complex binding

complement binding [inference]

complement component C1q complex binding

carbohydrate binding [inference]

polysaccharide binding [inference]

(1->3)-beta-D-glucan binding

protein-containing complex binding [inference]

complement component C1q complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Pentraxin-related protein PTX3

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
complement component C1q complex binding
immune response
negative regulation by host of viral process

Displaying **all 3** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
Pentraxin-related protein PTX3
Pentraxin-related

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050073	invasive aspergillosis	Alliance of Genome Resources
DOID:1485	cystic fibrosis	Alliance of Genome Resources

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026