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Guidelines

MIRAGE

SH3 and multiple ankyrin repeat domains 3

Summary

Gene Symbol

Shank3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

58234

PubChem

58234

Alliance of Genome Resources

MGI:1930016

Annotation

Keyword

3D-structure
ANK repeat
Actin-binding
Alternative promoter usage
Alternative splicing
Cell projection
Coiled coil
Cytoplasm
Methylation
Phosphoprotein
Reference proteome
Repeat
SH3 domain
Synapse

Proteins

Displaying 1 entry
UniProt	Protein Name
Q4ACU6	Proline-rich synapse-associated protein 2 SPANK-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 65 in total

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GO Term	Evidence Code	PMID
MAPK cascade	IGI
embryonic epithelial tube formation	IGI
synapse assembly	IMP
learning or memory	IMP
learning	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

MAPK cascade

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cell population proliferation [inference]

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

forebrain neuron differentiation [inference]

striatal medium spiny neuron differentiation

GABAergic neuron differentiation [inference]

striatal medium spiny neuron differentiation

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

glutamate receptor clustering [inference]

AMPA glutamate receptor clustering

guanylate kinase-associated protein clustering

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle assembly [inference]

postsynaptic specialization assembly [inference]

postsynaptic density assembly

postsynaptic specialization organization [inference]

postsynaptic density organization [inference]

postsynaptic density assembly

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

postsynaptic specialization assembly [inference]

postsynaptic density assembly

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

organelle assembly [inference]

postsynaptic specialization assembly [inference]

postsynaptic density assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendritic spine morphogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

dendritic spine morphogenesis

neuron projection organization [inference]

dendritic spine organization [inference]

dendritic spine morphogenesis

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

negative regulation of cell volume

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

synapse organization

synapse assembly

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

postsynapse organization [inference]

dendritic spine organization [inference]

dendritic spine morphogenesis

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of touch

cognition [inference]

learning or memory

associative learning

observational learning [inference]

imitative learning [inference]

vocal learning

memory

learned vocalization behavior or vocal learning [inference]

vocal learning

neuromuscular process [inference]

neuromuscular process controlling balance

behavior [inference]

learning or memory

associative learning

observational learning [inference]

imitative learning [inference]

vocal learning

memory

learned vocalization behavior or vocal learning [inference]

vocal learning

locomotory behavior

locomotory exploration behavior

mechanosensory behavior [inference]

auditory behavior [inference]

vocal learning

exploration behavior

locomotory exploration behavior

vocalization behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

brain morphogenesis

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendritic spine morphogenesis

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

epithelial tube formation [inference]

embryonic epithelial tube formation

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

forebrain neuron differentiation [inference]

striatal medium spiny neuron differentiation

GABAergic neuron differentiation [inference]

striatal medium spiny neuron differentiation

locomotion

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis [inference]

negative regulation of cell volume

response to stimulus [inference]

response to chemical [inference]

response to peptide [inference]

response to cytokine [inference]

response to interleukin-17

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

glutamate receptor clustering [inference]

AMPA glutamate receptor clustering

guanylate kinase-associated protein clustering

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

glutamate receptor clustering [inference]

AMPA glutamate receptor clustering

guanylate kinase-associated protein clustering

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of glutamate receptor signaling pathway [inference]

positive regulation of glutamate receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of synaptic transmission [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of long-term synaptic potentiation

positive regulation of long-term synaptic potentiation

regulation of long-term synaptic depression

negative regulation of synaptic transmission [inference]

long-term synaptic depression

positive regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of localization [inference]

regulation of protein localization [inference]

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

regulation of glutamate receptor clustering [inference]

regulation of AMPA glutamate receptor clustering

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

regulation of glutamate receptor clustering [inference]

regulation of AMPA glutamate receptor clustering

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of synaptic transmission [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of synaptic transmission [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of cellular component organization [inference]

positive regulation of synapse structural plasticity

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of dendritic spine development

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of glutamate receptor signaling pathway [inference]

positive regulation of glutamate receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of behavioral fear response

regulation of fear response [inference]

regulation of behavioral fear response

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of dendritic spine morphogenesis

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of dendritic spine development

regulation of dendritic spine development [inference]

positive regulation of dendritic spine development

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

MAPK cascade

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of glutamate receptor signaling pathway [inference]

positive regulation of glutamate receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of synaptic transmission [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of long-term synaptic potentiation

positive regulation of long-term synaptic potentiation

regulation of long-term synaptic depression

negative regulation of synaptic transmission [inference]

long-term synaptic depression

positive regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly

regulation of cellular component biogenesis [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of synaptic transmission [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of cellular component organization [inference]

positive regulation of synapse structural plasticity

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of dendritic spine morphogenesis

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly

regulation of synapse organization [inference]

regulation of synapse structural plasticity [inference]

positive regulation of synapse structural plasticity

regulation of postsynapse organization

regulation of dendritic spine morphogenesis

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly

positive regulation of cellular component organization [inference]

positive regulation of synapse structural plasticity

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

regulation of glutamate receptor clustering [inference]

regulation of AMPA glutamate receptor clustering

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of behavior [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of fear response [inference]

regulation of behavioral fear response

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of biological quality [inference]

regulation of membrane potential [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of synaptic plasticity

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of long-term synaptic potentiation

positive regulation of long-term synaptic potentiation

regulation of long-term synaptic depression

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

negative regulation of cell volume

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
cytoplasm	IEA
plasma membrane	IDA
postsynaptic density	ISS
postsynaptic density	ISO
postsynaptic density	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

ciliary membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendritic spine

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

intracellular organelle [inference]

intracellular membraneless organelle [inference]

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

postsynaptic specialization [inference]

postsynaptic density

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor binding	ISO
actin binding
protein binding	IPI
zinc ion binding	ISS
zinc ion binding	ISO

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of synapse [inference]

structural constituent of postsynapse [inference]

structural constituent of postsynaptic specialization [inference]

structural constituent of postsynaptic density

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding

glutamate receptor binding [inference]

ionotropic glutamate receptor binding

cytoskeletal protein binding [inference]

actin binding

protein domain specific binding [inference]

SH3 domain binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity [inference]

signaling receptor complex adaptor activity [inference]

synaptic receptor adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sh3 and multiple ankyrin repeat

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ionotropic glutamate receptor binding
synaptic receptor adaptor activity

Displaying **all 2** entries
InterPro
PDZ domain
PDZ superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0080354	Phelan-McDermid syndrome	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026