GlyCosmos Portal

Submissions

aldehyde dehydrogenase 18 family member A1

Summary

Gene Symbol

ALDH18A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5832

KEGG Gene ID

PubChem

5832

Alliance of Genome Resources

HGNC:9722

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Disease variant
Hereditary spastic paraplegia
Intellectual disability
Kinase
Mitochondrion
Multifunctional enzyme
NADP
Oxidoreductase
Proline biosynthesis
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P54886	Aldehyde dehydrogenase family 18 member A1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
glutamate metabolic process	IMP
ornithine biosynthetic process	IMP
amino acid biosynthetic process	IEA
response to temperature stimulus	IEA
citrulline biosynthetic process	IMP

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

amino acid biosynthetic process

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-proline biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

proteinogenic amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-proline biosynthetic process

non-proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-proline biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-proline biosynthetic process

proteinogenic amino acid metabolic process [inference]

L-proline metabolic process [inference]

L-proline biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-proline biosynthetic process

non-proteinogenic amino acid metabolic process [inference]

citrulline metabolic process [inference]

citrulline biosynthetic process

ornithine metabolic process [inference]

ornithine biosynthetic process

non-proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid metabolic process [inference]

citrulline metabolic process [inference]

citrulline biosynthetic process

glutamate metabolic process

ornithine metabolic process [inference]

ornithine biosynthetic process

L-amino acid metabolic process [inference]

L-proline metabolic process [inference]

L-proline biosynthetic process

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-proline biosynthetic process

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-proline biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

proteinogenic amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-proline biosynthetic process

non-proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-proline biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

glutamate metabolic process

carboxylic acid biosynthetic process [inference]

proteinogenic amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-proline biosynthetic process

non-proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-proline biosynthetic process

proteinogenic amino acid metabolic process [inference]

L-proline metabolic process [inference]

L-proline biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-proline biosynthetic process

non-proteinogenic amino acid metabolic process [inference]

citrulline metabolic process [inference]

citrulline biosynthetic process

ornithine metabolic process [inference]

ornithine biosynthetic process

non-proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid metabolic process [inference]

citrulline metabolic process [inference]

citrulline biosynthetic process

glutamate metabolic process

ornithine metabolic process [inference]

ornithine biosynthetic process

L-amino acid metabolic process [inference]

L-proline metabolic process [inference]

L-proline biosynthetic process

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-proline biosynthetic process

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-proline biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

proteinogenic amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-proline biosynthetic process

non-proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-proline biosynthetic process

response to stimulus [inference]

response to abiotic stimulus [inference]

response to temperature stimulus

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
cytoplasm	IEA
mitochondrion	IDA
mitochondrion	IBA
mitochondrion	IEA
mitochondrion	HTP

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

mitochondrial inner membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 15 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
RNA binding	HDA
catalytic activity	IEA
glutamate 5-kinase activity	IDA
glutamate 5-kinase activity	IMP
glutamate 5-kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity

oxidoreductase activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity

amino acid kinase activity [inference]

glutamate 5-kinase activity

phosphotransferase activity, carboxyl group as acceptor [inference]

glutamate 5-kinase activity

binding [inference]

nucleic acid binding [inference]

RNA binding

protein binding

identical protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Delta-1-pyrroline-5-carboxylate synthase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
ATP binding
L-proline biosynthetic process
amino acid biosynthetic process
glutamate 5-kinase activity
kinase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
oxidoreductase activity
proline biosynthetic process

Displaying **all 8** entries
InterPro
Acetylglutamate kinase-like superfamily
Aldehyde dehydrogenase domain
Aldehyde dehydrogenase, C-terminal
Aldehyde dehydrogenase, N-terminal
Aldehyde/histidinol dehydrogenase
Aspartate/glutamate/uridylate kinase
GPR domain
Gamma-glutamyl phosphate reductase GPR, conserved site

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:83	cataract	Alliance of Genome Resources
DOID:1283	enterocele	Alliance of Genome Resources
DOID:0070131	autosomal dominant cutis laxa 3	Alliance of Genome Resources
DOID:0110824	hereditary spastic paraplegia 9A	Alliance of Genome Resources
DOID:2476	hereditary spastic paraplegia	Alliance of Genome Resources
DOID:0070143	autosomal recessive cutis laxa type III	Alliance of Genome Resources
DOID:0070132	autosomal recessive cutis laxa type IIIA	Alliance of Genome Resources
DOID:0110825	hereditary spastic paraplegia 9B	Alliance of Genome Resources