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aggrecan

Summary

Gene Symbol

Acan

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

58968

KEGG Gene ID

[""]

PubChem

58968

Alliance of Genome Resources

RGD:68358

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disulfide bond
EGF-like domain
Extracellular matrix
Hyaluronic acid
Immunoglobulin domain
Lectin
Metal-binding
Proteoglycan
Proteomics identification
Reference proteome
Repeat
Signal
Sushi

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P07897	Cartilage-specific proteoglycan core protein
D4A7Y1	Cartilage-specific proteoglycan core protein
F1LQI4	Cartilage-specific proteoglycan core protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
skeletal system development	IBA
cartilage condensation	ISO
ossification	IEP
chondrocyte development	ISO
cell adhesion	IEA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

chondroblast differentiation

cell development [inference]

chondrocyte development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

cell aggregation [inference]

cartilage condensation

multicellular organismal process [inference]

ossification

developmental process [inference]

anatomical structure development [inference]

spinal cord development

cell development [inference]

chondrocyte development

animal organ development [inference]

system development [inference]

cellular developmental process [inference]

cell differentiation [inference]

chondroblast differentiation

cell development [inference]

chondrocyte development

response to stimulus [inference]

response to external stimulus [inference]

response to mechanical stimulus

response to abiotic stimulus [inference]

response to pH [inference]

response to acidic pH

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus

response to chemical [inference]

response to xenobiotic stimulus

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
extracellular region	IDA
extracellular region	IBA
basement membrane	ISO
basement membrane	IEA
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

cell junction [inference]

synapse

external encapsulating structure [inference]

extracellular matrix

basement membrane

specialized extracellular matrix [inference]

synapse-associated extracellular matrix [inference]

perisynaptic extracellular matrix

perineuronal net

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular matrix structural constituent	ISO
calcium ion binding	IDA
calcium ion binding	IEA
hyaluronic acid binding	IEA
carbohydrate binding	IEA

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

carbohydrate binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

hyaluronic acid binding

cation binding [inference]

metal ion binding

calcium ion binding

organic acid binding [inference]

carboxylic acid binding [inference]

hyaluronic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

aggrecan core protein

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 6** entries
Gene Ontology
calcium ion binding
central nervous system development
hyaluronic acid binding
metal ion binding
positive regulation of neuroblast proliferation
skeletal system development

Displaying entries **1 - 10** of 16 in total

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InterPro
Aggrecan/versican, C-type lectin-like domain
C-type lectin fold
C-type lectin, conserved site
C-type lectin-like/link domain superfamily
C-type lectin-like
EGF-like calcium-binding domain
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Immunoglobulin V-set domain
Immunoglobulin subtype

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
neuronal cell body	PMID:22306080
extracellular space	PMID:20603097
perineuronal net	PMID:18364019

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:90	degenerative disc disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements