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MIRAGE
interleukin 21
Summary
- Gene Symbol
-
- IL21
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cytokine
- Disease variant
- Disulfide bond
- Glycoprotein
- Proteomics identification
- Reference proteome
- Secreted
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| Q9HBE4 |
|
| A0A224B028 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| natural killer cell differentiation |
|
|
| positive regulation of cytokine production |
|
|
| positive regulation of cytokine production |
|
|
| positive regulation of cytokine production |
|
|
| germinal center B cell differentiation |
|
GO Hierarchy
biological process
immune system process [inference]
cellular process [inference]
multicellular organismal process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of cellular process [inference]
positive regulation of response to stimulus [inference]
positive regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of response to biotic stimulus [inference]
regulation of response to external stimulus [inference]
positive regulation of response to stimulus [inference]
regulation of immune response [inference]
regulation of response to stress [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region |
|
|
| extracellular region |
|
|
| extracellular region |
|
|
| obsolete extracellular space |
|
|
| plasma membrane |
|
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytokine activity |
|
|
| cytokine receptor binding |
|
|
| cytokine receptor binding |
|
|
| interleukin-2 receptor binding |
|
|
| protein binding |
|
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- interleukin-21
- Functional Category
-
- G: Carbohydrate transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cytokine activity |
| cytokine receptor binding |
| immune response |
| positive regulation of natural killer cell mediated cytotoxicity |
| InterPro |
|---|
| Four-helical cytokine-like, core |
| Interleukin-15/Interleukin-21 family |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0081153 | common variable immunodeficiency 11 | |
| DOID:2841 | asthma | |
| DOID:684 | hepatocellular carcinoma | |
| DOID:9074 | systemic lupus erythematosus |
