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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

ribonuclease A family member 3

Summary

Gene Symbol

RNASE3

Organism

Homo sapiens (human)

External Links

NCBI Gene

6037

KEGG Gene ID

PubChem

6037

Alliance of Genome Resources

HGNC:10046

Annotation

Keyword

3D-structure
Antibiotic
Direct protein sequencing
Disulfide bond
Endonuclease
Glycoprotein
Nitration
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P12724	Ribonuclease 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
innate immune response in mucosa	IDA
innate immune response in mucosa	IBA
RNA catabolic process	TAS
chemotaxis	IBA
antibacterial humoral response	IDA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

organ or tissue specific immune response [inference]

mucosal immune response [inference]

innate immune response in mucosa

humoral immune response [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

induction of bacterial agglutination

antimicrobial humoral immune response mediated by antimicrobial peptide

innate immune response

innate immune response in mucosa

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

nucleic acid catabolic process [inference]

RNA catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

nucleic acid catabolic process [inference]

RNA catabolic process

locomotion [inference]

taxis [inference]

chemotaxis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

induction of bacterial agglutination

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

induction of bacterial agglutination

antimicrobial humoral immune response mediated by antimicrobial peptide

innate immune response

innate immune response in mucosa

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to bacterium [inference]

antibacterial humoral response

induction of bacterial agglutination

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

induction of bacterial agglutination

antimicrobial humoral immune response mediated by antimicrobial peptide

innate immune response

innate immune response in mucosa

immune response [inference]

organ or tissue specific immune response [inference]

mucosal immune response [inference]

innate immune response in mucosa

humoral immune response [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

induction of bacterial agglutination

antimicrobial humoral immune response mediated by antimicrobial peptide

innate immune response

innate immune response in mucosa

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

induction of bacterial agglutination

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

induction of bacterial agglutination

antimicrobial humoral immune response mediated by antimicrobial peptide

innate immune response

innate immune response in mucosa

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

induction of bacterial agglutination

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

induction of bacterial agglutination

antimicrobial humoral immune response mediated by antimicrobial peptide

innate immune response

innate immune response in mucosa

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	IDA
extracellular region	IBA
extracellular region	IEA
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
lipopolysaccharide binding	IDA
nucleic acid binding	IEA
endonuclease activity
RNA nuclease activity	TAS
RNA nuclease activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

catalytic activity, acting on RNA [inference]

RNA nuclease activity

binding [inference]

nucleic acid binding

lipid binding [inference]

lipopolysaccharide binding

carbohydrate derivative binding [inference]

lipopolysaccharide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

eosinophil cationic protein

Functional Category

J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
RNA nuclease activity
chemotaxis
defense response to Gram-positive bacterium
endonuclease activity
hydrolase activity
innate immune response in mucosa
nuclease activity

Displaying **all 4** entries
InterPro
Pancreatic ribonuclease
Ribonuclease A, active site
Ribonuclease A-domain
Ribonuclease A-like domain superfamily

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	13587	MGI:108020
Mus musculus	53877	MGI:1858238
Mus musculus	13586	MGI:108021
Mus musculus	54159	MGI:1858598
Mus musculus	53876	MGI:1858237
Rattus norvegicus	192264	RGD:621580

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026