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MIRAGE

exocyst complex component 4

Summary

Gene Symbol

EXOC4

Organism

Homo sapiens (human)

External Links

NCBI Gene

60412

KEGG Gene ID

PubChem

60412

Alliance of Genome Resources

HGNC:30389

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell projection
Coiled coil
Cytoskeleton
Direct protein sequencing
Exocytosis
Phosphoprotein
Protein transport
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q96A65	Exocyst complex component Sec8
Q6NX51

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
mitotic cytokinesis	NAS
protein targeting to membrane	IEA
exocytosis	IBA
exocytosis	IEA
Golgi to plasma membrane transport	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

vesicle-mediated transport [inference]

exocytosis

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to plasma membrane transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

mitotic cytokinesis

mitotic cell cycle process [inference]

mitotic cytokinesis

membrane docking [inference]

organelle localization by membrane tethering [inference]

vesicle docking [inference]

vesicle docking involved in exocytosis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to ciliary membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport

transmembrane transport [inference]

protein transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

membrane organization [inference]

membrane fission

vesicle tethering [inference]

vesicle tethering involved in exocytosis

exocytic process [inference]

export from cell [inference]

secretion by cell [inference]

exocytosis

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

formation of primary germ layer [inference]

mesoderm formation [inference]

paraxial mesoderm formation

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport

protein transmembrane transport

protein localization to organelle [inference]

protein localization to cilium [inference]

protein localization to ciliary membrane

protein localization to membrane [inference]

protein localization to ciliary membrane

protein localization to cell periphery [inference]

protein localization to ciliary membrane

establishment of localization [inference]

transport [inference]

protein transport

protein transmembrane transport

vesicle-mediated transport [inference]

exocytosis

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to plasma membrane transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport

secretion [inference]

secretion by cell [inference]

exocytosis

transmembrane transport [inference]

protein transmembrane transport

export from cell [inference]

secretion by cell [inference]

exocytosis

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport

protein transmembrane transport

establishment of protein localization to membrane [inference]

protein targeting to membrane

organelle localization [inference]

organelle localization by membrane tethering [inference]

vesicle docking [inference]

vesicle docking involved in exocytosis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to ciliary membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

Displaying entries **6 - 10** of 17 in total

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GO Term	Evidence Code	PMID
centrosome	IEA
cytosol	TAS
plasma membrane	TAS
microvillus	IEA
membrane	HDA

GO Hierarchy

cellular component

protein-containing complex [inference]

vesicle tethering complex [inference]

exocyst

cellular anatomical structure [inference]

cytoplasm

microtubule organizing center [inference]

centrosome

cytosol

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

non-motile cilium [inference]

9+0 non-motile cilium

actin-based cell projection [inference]

microvillus

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

non-motile cilium [inference]

9+0 non-motile cilium

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI
PDZ domain binding	IEA
GTP-dependent protein binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

protein domain specific binding [inference]

PDZ domain binding

GTP-dependent protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

exocyst complex component

Functional Category

H: Coenzyme transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
Golgi to plasma membrane transport
chemical synaptic transmission
protein targeting to membrane
vesicle docking involved in exocytosis
vesicle tethering involved in exocytosis

Displaying **all 2** entries
InterPro
Exocyst complex component Sec8, N-terminal
Exocyst complex component Sec8/EXOC4

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	172924	WB:WBGene00004753
Saccharomyces cerevisiae S288C	856168	SGD:S000006259

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026