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glutamate metabotropic receptor 8

Summary

Gene Symbol

Grm8

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

60590

PubChem

60590

Alliance of Genome Resources

RGD:619858

Annotation

Keyword

Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Isopeptide bond
Reference proteome
Sensory transduction
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P70579
A6IEA3
F1LRA6

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	ISS
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	ISO
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	TAS	16084932
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of pain

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception of pain [inference]

detection of mechanical stimulus involved in sensory perception of pain

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
plasma membrane	IDA	16045496
plasma membrane	IBA
plasma membrane	IEA
presynaptic membrane	IDA	15275822
neuronal cell body	IDA	12443992

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse [inference]

cell body [inference]

neuronal cell body

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GO Term	Evidence Code	PMID
group III metabotropic glutamate receptor activity	ISO
group III metabotropic glutamate receptor activity	IDA	9875342
group III metabotropic glutamate receptor activity	IBA
G protein-coupled receptor activity	ISS
G protein-coupled receptor activity	ISO

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled glutamate receptor activity [inference]

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [inference]

group III metabotropic glutamate receptor activity

glutamate receptor activity

G protein-coupled glutamate receptor activity [inference]

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [inference]

group III metabotropic glutamate receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

metabotropic glutamate receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of synaptic transmission, glutamatergic

Displaying **all 6** entries
InterPro
GPCR family 3, C-terminal
GPCR, family 3, nine cysteines domain superfamily
GPCR, family 3, nine cysteines domain
GPCR, family 3
Periplasmic binding protein-like I
Receptor, ligand binding region

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
neuronal cell body	PMID:12443992

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:11832	visual epilepsy	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 99 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	2912	WB:WBGene00003232
Caenorhabditis elegans	2913	WB:WBGene00003232
Caenorhabditis elegans	2914	WB:WBGene00003232
Caenorhabditis elegans	2916	WB:WBGene00003232
Caenorhabditis elegans	2917	WB:WBGene00003232
Homo sapiens	2918	ZFIN:ZDB-GENE-110421-2	HUMAN91149
Mus musculus	14823	ZFIN:ZDB-GENE-110421-3	MOUSE49701
Caenorhabditis elegans	24415	WB:WBGene00003232
Caenorhabditis elegans	24416	WB:WBGene00003232
Caenorhabditis elegans	24417	WB:WBGene00003232