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replication protein A2

Summary

Gene Symbol

RPA2

Organism

Homo sapiens (human)

External Links

NCBI Gene

6118

PubChem

6118

Alliance of Genome Resources

HGNC:10290

JoGo

RPA2

TogoVar

RPA2

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
DNA recombination
DNA repair
DNA replication
DNA-binding
Direct protein sequencing
Isopeptide bond
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P15927	Replication factor A protein 2 Replication protein A 34 kDa subunit
B4DUL2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
telomere maintenance	NAS	17959650
telomere maintenance	IC	24747047
telomere maintenance	IMP	17959650
double-strand break repair via homologous recombination	NAS	17765923
double-strand break repair via homologous recombination	IMP	17765923

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cell cycle process [inference]

mitotic cell cycle process [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

telomere organization [inference]

telomere maintenance

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of DNA damage checkpoint

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of DNA damage checkpoint

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination

regulation of DNA damage checkpoint

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of DNA damage checkpoint

regulation of metabolic process [inference]

regulation of macromolecule metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination

regulation of DNA repair [inference]

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination

regulation of DNA repair [inference]

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

regulation of cell cycle phase transition [inference]

regulation of cell cycle checkpoint [inference]

regulation of DNA damage checkpoint

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

regulation of cell cycle G1/S phase transition [inference]

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle [inference]

mitotic G1/S transition checkpoint signaling [inference]

mitotic G1 DNA damage checkpoint signaling

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination

regulation of DNA damage checkpoint

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
chromosome, telomeric region	IDA	17959650
chromosome, telomeric region	HDA	19135898
chromatin	IDA	10336450
nucleus	IDA	10982866
nucleoplasm	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

DNA replication factor A complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nuclear body

PML body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nuclear body

PML body

site of DNA damage [inference]

site of double-strand break

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
damaged DNA binding	IDA	27723717 27723720 7700386
single-stranded DNA binding	ISS
single-stranded DNA binding	IC	2406247
single-stranded DNA binding	IDA	19010961
single-stranded DNA binding	IBA

GO Hierarchy

molecular function

binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

single-stranded DNA binding

sequence-specific single stranded DNA binding [inference]

single-stranded telomeric DNA binding [inference]

G-rich strand telomeric DNA binding

sequence-specific DNA binding [inference]

telomeric repeat DNA binding

single-stranded telomeric DNA binding [inference]

G-rich strand telomeric DNA binding

sequence-specific single stranded DNA binding [inference]

single-stranded telomeric DNA binding [inference]

G-rich strand telomeric DNA binding

protein binding

enzyme binding

phosphatase binding [inference]

protein phosphatase binding

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

replication protein A

Functional Category

I: Lipid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
DNA recombination
DNA repair

Displaying **all 6** entries
InterPro
Nucleic acid-binding, OB-fold
Replication factor A protein 2
Replication factor A protein-like
Replication protein A, C-terminal
Winged helix DNA-binding domain superfamily
Winged helix-like DNA-binding domain superfamily

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements