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MIRAGE
complement factor B

Summary
Gene Symbol
  • CFB
Organism
Homo sapiens (human)
NCBI Gene
629
KEGG Gene ID
[""]
PubChem
629
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Age-related macular degeneration
  • Alternative splicing
  • Cleavage on pair of basic residues
  • Complement alternate pathway
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycation
  • Glycoprotein
  • Hemolytic uremic syndrome
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Secreted
  • Serine protease
  • Signal
  • Sushi
  • Zymogen
Proteins
Displaying all 2 entries
UniProt Protein Name
A0A1U9X7H8
  • C3/C5 convertase
P00751
  • C3/C5 convertase
  • Glycine-rich beta glycoprotein
  • PBF2
  • Properdin factor B
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 14 in total
GO Term Evidence Code PMID
activation of membrane attack complex
pre-B cell differentiation
proteolysis
complement activation
complement activation
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
complement factor B
Functional Category
  • E: Amino acid transport and metabolism
  • G: Carbohydrate transport and metabolism
  • T: Signal transduction mechanisms
Displaying all 3 entries
Gene Ontology
complement activation
proteolysis
serine-type endopeptidase activity
Displaying all 9 entries
InterPro
Complement B/C2
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Sushi/SCR/CCP domain
von Willebrand factor A-like domain superfamily
von Willebrand factor, type A
Disease
Disease Ontology
Displaying entries 1 - 10 of 12 in total
DO ID Disease Name Source
DOID:0080301 atypical hemolytic-uremic syndrome
DOID:0110026 age related macular degeneration 14
DOID:10923 sickle cell anemia
DOID:10976 membranous glomerulonephritis
DOID:1407 anterior uveitis
DOID:2920 membranoproliferative glomerulonephritis
DOID:2986 IgA glomerulonephritis
DOID:4448 macular degeneration
DOID:8893 psoriasis
DOID:8947 diabetic retinopathy
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026