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acyl-CoA synthetase medium chain family member 3

Summary

Gene Symbol

ACSM3

Aliases

Organism

Homo sapiens (human)

External Links

NCBI Gene

6296

HGNC

10522

KEGG Gene ID

hsa:6296

PubChem

6296

Alliance of Genome Resources

HGNC:10522

JoGo

ACSM3

TogoVar

ACSM3

Annotation

Keyword

ATP-binding
Acetylation
Alternative splicing
Fatty acid metabolism
Ligase
Magnesium
Metal-binding
Mitochondrion
Proteomics identification
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q53FZ2	Acyl-CoA synthetase medium-chain family member 3 Butyrate--CoA ligase 3 Butyryl-coenzyme A synthetase 3 Middle-chain acyl-CoA synthetase 3 Propionate--CoA ligase Protein SA homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
fatty acid biosynthetic process	IBA
acyl-CoA metabolic process	IBA
regulation of blood pressure	NAS
regulation of blood pressure	TAS
cholesterol homeostasis	NAS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

sulfur compound metabolic process [inference]

acyl-CoA metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process

lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process

purine-containing compound metabolic process [inference]

acyl-CoA metabolic process

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

biological regulation [inference]

regulation of biological quality [inference]

regulation of blood pressure

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitochondrion	IDA
mitochondrion	IEA
mitochondrion	HTP
mitochondrial matrix	ISS
mitochondrial matrix	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
fatty-acyl-CoA synthase activity	IBA
protein binding	IPI
ATP binding
fatty acid ligase activity	IBA
fatty acid ligase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

C-acyltransferase activity [inference]

fatty-acyl-CoA synthase activity

transferase activity, transferring sulphur-containing groups [inference]

CoA-transferase activity [inference]

propionate CoA-transferase activity

ligase activity [inference]

ligase activity, forming carbon-sulfur bonds [inference]

acid-thiol ligase activity

fatty acid ligase activity

fatty acid-CoA ligase activity [inference]

short-chain fatty acid-CoA ligase activity [inference]

medium-chain fatty acid-CoA ligase activity

CoA-ligase activity

fatty acid-CoA ligase activity [inference]

short-chain fatty acid-CoA ligase activity [inference]

medium-chain fatty acid-CoA ligase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

fatty acid ligase activity

fatty acid-CoA ligase activity [inference]

short-chain fatty acid-CoA ligase activity [inference]

medium-chain fatty acid-CoA ligase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

acyl-coenzyme a synthetase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 7** entries
Gene Ontology
CoA-ligase activity
acid-thiol ligase activity
acyl-CoA metabolic process
fatty acid ligase activity
fatty-acyl-CoA synthase activity
ligase activity
lipid metabolic process

Displaying **all 5** entries
InterPro
AMP-binding enzyme, C-terminal domain superfamily
AMP-binding enzyme, C-terminal domain
AMP-binding, conserved site
AMP-dependent synthetase/ligase domain
ANL, N-terminal domain