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MIRAGE

G protein-coupled receptor 35

Summary

Gene Symbol

Gpr35

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

64095

KEGG Gene ID

PubChem

64095

Alliance of Genome Resources

MGI:1929509

Annotation

Keyword

Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Mitochondrion outer membrane
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
Q8CB97
Q9ES90	Kynurenic acid receptor
Q3TU48
Q3TBY9
Q8BS98

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
monocyte chemotaxis	ISS
monocyte chemotaxis	ISO
monocyte chemotaxis	IEA
response to ischemia	ISO
response to ischemia	IEA

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

mononuclear cell migration [inference]

monocyte chemotaxis

macrophage migration [inference]

macrophage chemotaxis

myeloid leukocyte migration [inference]

monocyte chemotaxis

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

macrophage migration [inference]

macrophage chemotaxis

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

leukocyte cell-cell adhesion [inference]

leukocyte adhesion to vascular endothelial cell

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

chemokine-mediated signaling pathway

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

mononuclear cell migration [inference]

monocyte chemotaxis

macrophage migration [inference]

macrophage chemotaxis

myeloid leukocyte migration [inference]

monocyte chemotaxis

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

macrophage migration [inference]

macrophage chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

response to stimulus [inference]

response to stress [inference]

response to ischemia

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

regulation of voltage-gated calcium channel activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

negative regulation of calcium ion transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of calcium ion transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of transport [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of calcium ion transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of biological process [inference]

negative regulation of action potential [inference]

negative regulation of neuronal action potential

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of transport [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of calcium ion transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

chemokine-mediated signaling pathway

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

regulation of transmission of nerve impulse [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

regulation of neuronal action potential [inference]

negative regulation of neuronal action potential

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

regulation of voltage-gated calcium channel activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

regulation of striated muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

regulation of cardiac muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

regulation of transmission of nerve impulse [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

regulation of neuronal action potential [inference]

negative regulation of neuronal action potential

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

regulation of action potential [inference]

negative regulation of action potential [inference]

negative regulation of neuronal action potential

regulation of neuronal action potential [inference]

negative regulation of neuronal action potential

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

regulation of membrane potential [inference]

regulation of action potential [inference]

negative regulation of action potential [inference]

negative regulation of neuronal action potential

regulation of neuronal action potential [inference]

negative regulation of neuronal action potential

regulation of molecular function [inference]

regulation of transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

regulation of voltage-gated calcium channel activity [inference]

negative regulation of voltage-gated calcium channel activity

negative regulation of molecular function [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of calcium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated calcium channel activity

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
mitochondrial outer membrane	IEA
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	IDA
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor activity	ISS
G protein-coupled receptor activity	ISO
G protein-coupled receptor activity	IBA
G protein-coupled receptor activity	IEA
chemokine receptor activity	IEA

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-X-C chemokine receptor activity

G protein-coupled receptor activity

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity

C-X-C chemokine receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-X-C chemokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G-protein coupled receptor 35

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
chemokine receptor activity
chemokine-mediated signaling pathway
positive regulation of Rho protein signal transduction

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	180841	WB:WBGene00016570
Homo sapiens	2859	HGNC:4492

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Last updated: April 6, 2026