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Guidelines

MIRAGE

endoplasmic reticulum aminopeptidase 2

Summary

Gene Symbol

ERAP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

64167

KEGG Gene ID

PubChem

64167

Alliance of Genome Resources

HGNC:29499

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative splicing
Aminopeptidase
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Metal-binding
Metalloprotease
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q6P179	Leukocyte-derived arginine aminopeptidase
B2R769
A0AAQ5BHS6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **11 - 11** of 11 in total

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GO Term	Evidence Code	PMID
peptide catabolic process	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

antigen processing and presentation [inference]

antigen processing and presentation of endogenous antigen [inference]

antigen processing and presentation of endogenous peptide antigen [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of peptide antigen via MHC class I

antigen processing and presentation of endogenous peptide antigen via MHC class I

antigen processing and presentation of endogenous peptide antigen [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I

cellular process [inference]

metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

catabolic process [inference]

peptide catabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

response to stimulus [inference]

immune response [inference]

adaptive immune response

biological regulation [inference]

regulation of biological quality [inference]

regulation of blood pressure

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytoplasm	IEA
endoplasmic reticulum	IDA
endoplasmic reticulum lumen	TAS
endoplasmic reticulum lumen	IDA
endoplasmic reticulum lumen	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	EXP
aminopeptidase activity	IDA
aminopeptidase activity	IEA
protein binding	IPI
metallopeptidase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

metallopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

metallopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Aminopeptidase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 9** entries
Gene Ontology
aminopeptidase activity
hydrolase activity
metal ion binding
metalloaminopeptidase activity
metallopeptidase activity
peptide binding
peptide catabolic process
proteolysis
zinc ion binding

Displaying **all 7** entries
InterPro
Aminopeptidase N-like , N-terminal domain superfamliy
Aminopeptidase N-like , N-terminal domain
Aminopeptidase N-type
ERAP1-like C-terminal domain
Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
Peptidase M1, membrane alanine aminopeptidase
Peptidase M4/M1, CTD superfamily

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	173297	WB:WBGene00009865
Caenorhabditis elegans	179763	WB:WBGene00011587

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026