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gremlin 2, DAN family BMP antagonist

Summary

Gene Symbol

GREM2

Organism

Homo sapiens (human)

External Links

NCBI Gene

64388

KEGG Gene ID

PubChem

64388

Alliance of Genome Resources

HGNC:17655

Annotation

Keyword

Cytokine
Developmental protein
Disease variant
Disulfide bond
Glycoprotein
Heparin-binding
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H772	Cysteine knot superfamily 1, BMP antagonist 2 DAN domain family member 3 Protein related to DAN and cerberus

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
embryonic body morphogenesis	ISS
embryonic body morphogenesis	IEA
cytokine-mediated signaling pathway	ISS
cytokine-mediated signaling pathway	IEA
negative regulation of BMP signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation [inference]

determination of dorsal identity

developmental process [inference]

anatomical structure morphogenesis [inference]

body morphogenesis [inference]

embryonic body morphogenesis

embryonic morphogenesis [inference]

embryonic body morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of signaling receptor activity [inference]

regulation of cytokine activity

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of signaling receptor activity [inference]

regulation of cytokine activity

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of signaling receptor activity [inference]

regulation of cytokine activity

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

regulation of cytokine activity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	IBA
extracellular region	IEA
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
cytokine activity
heparin binding	ISS
heparin binding	IEA
BMP binding	IBA
identical protein binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytokine binding [inference]

BMP binding

identical protein binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

molecular sequestering activity [inference]

protein sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050591	tooth agenesis	Alliance of Genome Resources

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	23893	MGI:1344367

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026

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