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heparan sulfate-glucosamine 3-sulfotransferase 6

Summary

Gene Symbol

HS3ST6

Organism

Homo sapiens (human)

External Links

NCBI Gene

64711

GGDB ID

gg237

HGNC

14178

map

16p13.3

OMIM

619210

KEGG Gene ID

hsa:64711

PubChem

64711

Alliance of Genome Resources

HGNC:14178

JoGo

HS3ST6

TogoVar

HS3ST6

Annotation

Keyword

Disulfide bond
Glycoprotein
Golgi apparatus
Proteomics identification
Reference proteome
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96QI5	Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
blastocyst hatching
heparan sulfate proteoglycan biosynthetic process	TAS	https://reactome.org/content/detail/R-HSA-2076611
heparan sulfate proteoglycan biosynthetic process	IEA	http://purl.obolibrary.org/obo/go/references/0000107

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

multicellular organismal process [inference]

organism emergence from protective structure [inference]

hatching [inference]

blastocyst hatching

Displaying **all 2** entries
GO Term	Evidence Code	PMID
Golgi membrane	TAS	https://reactome.org/content/detail/R-HSA-2076611
Golgi membrane	IEA	http://purl.obolibrary.org/obo/go/references/0000044

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
sulfotransferase activity	IEA
[heparan sulfate]-glucosamine 3-sulfotransferase activity	ISS	http://purl.obolibrary.org/obo/go/references/0000024
[heparan sulfate]-glucosamine 3-sulfotransferase activity	TAS	https://reactome.org/content/detail/R-HSA-2076611
[heparan sulfate]-glucosamine 3-sulfotransferase activity	IBA	http://purl.obolibrary.org/obo/go/references/0000033
[heparan sulfate]-glucosamine 3-sulfotransferase activity	IEA	http://purl.obolibrary.org/obo/go/references/0000003 http://purl.obolibrary.org/obo/go/references/0000107 http://purl.obolibrary.org/obo/go/references/0000116

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

sulfotransferase activity

proteoglycan sulfotransferase activity [inference]

heparan sulfate sulfotransferase activity [inference]

[heparan sulfate]-glucosamine 3-sulfotransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

heparan sulfate glucosamine 3-O-sulfotransferase

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
sulfotransferase activity
transferase activity

Displaying **all 3** entries
InterPro
Heparan sulfate sulfotransferase
P-loop containing nucleoside triphosphate hydrolase
Sulfotransferase domain

GlycoGene Database (GGDB)

GGDB ID

gg237

Gene Symbol

HS3ST6

KEGG BRITE Database

Orthology

K09679

Name

[heparan sulfate]-glucosamine 3-sulfotransferase 6 [EC:2.8.2.-]

References

15303968

Rhea

RHEA:15461

3'-phosphoadenylyl sulfate

H⁺ + adenosine 3',5'-bisphosphate

Enzyme

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14735	hereditary angioedema	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying **all 8** entries
HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000282	Facial edema
HP:0002014	Diarrhea
HP:0002027	Abdominal pain
HP:0002572	Episodic vomiting
HP:0007514	Edema of the dorsum of hands
HP:0012027	Laryngeal edema
HP:0100665	Angioedema