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SKI2 subunit of superkiller complex

Summary

Gene Symbol

SKIC2

Organism

Homo sapiens (human)

External Links

NCBI Gene

6499

KEGG Gene ID

[""]

PubChem

6499

Alliance of Genome Resources

HGNC:10898

Annotation

Keyword

3D-structure
Cytoplasm
Disease variant
Helicase
Nucleus
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
H7C5N0
Q15477	Helicase-like protein
A0A1U9X8J1
A0A8V8TLC0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nuclear-transcribed mRNA catabolic process	IPI
RNA catabolic process	IEA
mRNA catabolic process	IEA
nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay	IDA
nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

cytoplasmic translational elongation [inference]

rescue of stalled cytosolic ribosome

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

macromolecule biosynthetic process [inference]

translational elongation [inference]

cytoplasmic translational elongation [inference]

rescue of stalled cytosolic ribosome

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

mRNA metabolic process [inference]

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

mRNA metabolic process [inference]

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle disassembly [inference]

ribosome disassembly [inference]

rescue of stalled cytosolic ribosome

cellular component disassembly [inference]

organelle disassembly [inference]

ribosome disassembly [inference]

rescue of stalled cytosolic ribosome

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [inference]

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, non-stop decay

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleus	EXP
nucleus	IEA
cytoplasm	NAS
cytoplasm	IEA
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

Ski complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nucleic acid binding	IEA
RNA binding	IEA
RNA helicase activity	TAS
RNA helicase activity	IBA
RNA helicase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

isomerase activity [inference]

macromolecular conformation isomerase activity [inference]

nucleic acid conformation isomerase activity [inference]

helicase activity [inference]

RNA helicase activity

3'-5' RNA helicase activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity [inference]

RNA helicase activity

3'-5' RNA helicase activity

catalytic activity, acting on RNA [inference]

RNA helicase activity

3'-5' RNA helicase activity

binding [inference]

nucleic acid binding

RNA binding

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity [inference]

RNA helicase activity

3'-5' RNA helicase activity

ATP-dependent activity, acting on RNA [inference]

RNA helicase activity

3'-5' RNA helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

helicase

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
RNA catabolic process
hydrolase activity
maturation of 5.8S rRNA
nucleotide binding

Displaying **all 8** entries
InterPro
ATP-dependent RNA helicase SKI2-like
ATP-dependent RNA helicase Ski2/MTR4, C-terminal
DEAD/DEAH box helicase domain
Exosome RNA helicase MTR4-like, beta-barrel domain
Exosome RNA helicase MTR4-like, stalk
Helicase superfamily 1/2, ATP-binding domain
Helicase, C-terminal domain-like
P-loop containing nucleoside triphosphate hydrolase