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solute carrier family 1 member 1

Summary

Gene Symbol

SLC1A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6505

KEGG Gene ID

PubChem

6505

Alliance of Genome Resources

HGNC:10939

Annotation

Keyword

3D-structure
Amino-acid transport
Cell membrane
Chloride
Disease variant
Endosome
Glycoprotein
Metal-binding
Phosphoprotein
Potassium
Proteomics identification
Reference proteome
Schizophrenia
Sodium
Symport
Synaptosome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P43005	Excitatory amino-acid carrier 1 Neuronal and epithelial glutamate transporter Sodium-dependent glutamate/aspartate transporter 3 Solute carrier family 1 member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 69 in total

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GO Term	Evidence Code	PMID
behavioral fear response
response to amphetamine	IEA
regulation of heart rate	IEA
glutathione biosynthetic process	IEA
superoxide metabolic process	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

cell surface receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled dopamine receptor signaling pathway

metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

modified amino acid metabolic process [inference]

glutathione metabolic process [inference]

glutathione biosynthetic process

modified amino acid biosynthetic process [inference]

glutathione biosynthetic process

sulfur compound metabolic process [inference]

glutathione metabolic process [inference]

glutathione biosynthetic process

sulfur compound biosynthetic process [inference]

glutathione biosynthetic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

modified amino acid biosynthetic process [inference]

glutathione biosynthetic process

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

sulfur compound biosynthetic process [inference]

glutathione biosynthetic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process [inference]

dopamine metabolic process

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

dopamine metabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

reactive oxygen species metabolic process [inference]

superoxide metabolic process

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

motor neuron apoptotic process

vesicle-mediated transport [inference]

vesicle-mediated transport to the plasma membrane [inference]

neurotransmitter receptor transport to plasma membrane

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

neurotransmitter receptor transport to plasma membrane

establishment of protein localization to membrane [inference]

neurotransmitter receptor transport to plasma membrane

vesicle-mediated transport to the plasma membrane [inference]

neurotransmitter receptor transport to plasma membrane

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to metal ion [inference]

cellular response to mercury ion

cellular response to nitrogen compound [inference]

cellular response to ammonium ion

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

cysteine transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

zinc ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

cysteine transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

heart process [inference]

heart contraction

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

conditioned place preference

memory

behavior [inference]

behavioral defense response [inference]

behavioral fear response

learning or memory [inference]

learning [inference]

associative learning [inference]

conditioned place preference

memory

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

blood vessel morphogenesis

anatomical structure formation involved in morphogenesis [inference]

retina layer formation

anatomical structure development [inference]

animal organ development [inference]

brain development

retina development in camera-type eye

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular zinc ion homeostasis

intracellular amino acid homeostasis [inference]

intracellular glutamate homeostasis

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular zinc ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular zinc ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular zinc ion homeostasis

intracellular amino acid homeostasis [inference]

intracellular glutamate homeostasis

inorganic ion homeostasis [inference]

intracellular zinc ion homeostasis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

behavioral defense response [inference]

behavioral fear response

response to oxidative stress [inference]

cellular response to oxidative stress

response to wounding [inference]

response to axon injury

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

response to external stimulus [inference]

reflex [inference]

righting reflex

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels

response to chemical [inference]

response to xenobiotic stimulus

response to metal ion [inference]

response to mercury ion [inference]

cellular response to mercury ion

cellular response to metal ion [inference]

cellular response to mercury ion

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to metal ion [inference]

cellular response to mercury ion

cellular response to nitrogen compound [inference]

cellular response to ammonium ion

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

response to anesthetic

response to nitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to alkaloid [inference]

response to isoquinoline alkaloid [inference]

response to morphine

response to cocaine [inference]

cellular response to cocaine

cellular response to alkaloid [inference]

cellular response to cocaine

response to ammonium ion [inference]

cellular response to ammonium ion

cellular response to nitrogen compound [inference]

cellular response to ammonium ion

cellular response to alkaloid [inference]

cellular response to cocaine

response to oxygen-containing compound [inference]

response to cocaine [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

response to bisphenol A [inference]

cellular response to bisphenol A

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to metal ion [inference]

cellular response to mercury ion

cellular response to nitrogen compound [inference]

cellular response to ammonium ion

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport to plasma membrane

protein localization to membrane [inference]

neurotransmitter receptor transport to plasma membrane

protein localization to cell periphery [inference]

neurotransmitter receptor transport to plasma membrane

protein-containing complex localization [inference]

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport to plasma membrane

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

zinc ion transport [inference]

zinc ion transmembrane transport

monoatomic cation transmembrane transport [inference]

zinc ion transmembrane transport

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

zinc ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

neurotransmitter transport

amino acid transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

cysteine transmembrane transport

acidic amino acid transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-glutamate import

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

neutral amino acid transport [inference]

cysteine transport

cysteine transmembrane transport

L-amino acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transmembrane transport

D-aspartate import across plasma membrane

vascular transport [inference]

transport across blood-brain barrier

protein transport [inference]

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport to plasma membrane

organic cation transport [inference]

cysteine transport

cysteine transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

organic anion transport [inference]

carboxylic acid transport [inference]

sulfur amino acid transport [inference]

cysteine transport

cysteine transmembrane transport

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-glutamate import

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-amino acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transmembrane transport

D-aspartate import across plasma membrane

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

cysteine transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

sulfur amino acid transport [inference]

cysteine transport

cysteine transmembrane transport

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-glutamate import

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-amino acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transmembrane transport

D-aspartate import across plasma membrane

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

cysteine transmembrane transport

vesicle-mediated transport [inference]

vesicle-mediated transport to the plasma membrane [inference]

neurotransmitter receptor transport to plasma membrane

transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

cysteine transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

zinc ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

cysteine transmembrane transport

transepithelial transport

nitrogen compound transport [inference]

sulfur amino acid transport [inference]

cysteine transport

cysteine transmembrane transport

L-amino acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transmembrane transport

D-aspartate import across plasma membrane

sulfur compound transport [inference]

sulfur amino acid transport [inference]

cysteine transport

cysteine transmembrane transport

import into cell

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

establishment of protein localization [inference]

protein transport [inference]

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport to plasma membrane

establishment of protein localization to membrane [inference]

neurotransmitter receptor transport to plasma membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

neurotransmitter receptor transport to plasma membrane

establishment of protein localization to membrane [inference]

neurotransmitter receptor transport to plasma membrane

vesicle-mediated transport to the plasma membrane [inference]

neurotransmitter receptor transport to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

postsynaptic modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein targeting [inference]

regulation of protein targeting to membrane

regulation of cellular localization [inference]

regulation of protein targeting to membrane

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of multicellular organismal process [inference]

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled dopamine receptor signaling pathway

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

postsynaptic modulation of chemical synaptic transmission

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of cellular localization [inference]

regulation of protein targeting to membrane

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate

positive regulation of heart rate

positive regulation of heart contraction [inference]

positive regulation of heart rate

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

positive regulation of multicellular organismal process [inference]

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

regulation of biological quality [inference]

regulation of heart rate

positive regulation of heart rate

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

Displaying entries **6 - 10** of 48 in total

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GO Term	Evidence Code	PMID
plasma membrane	IEA
cell surface	IEA
membrane	ISS
membrane	TAS
membrane	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

bounding membrane of organelle [inference]

endosome membrane [inference]

plasma membrane region [inference]

apical plasma membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

synapse

Schaffer collateral - CA1 synapse

neuron to neuron synapse [inference]

asymmetric synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

dendrite

neuron spine [inference]

dendritic spine

glial cell projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus

presynapse

axon terminus

postsynapse [inference]

dendritic spine

perisynaptic space

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
monoatomic anion channel activity	IEA
L-glutamate transmembrane transporter activity	IDA
L-glutamate transmembrane transporter activity	IBA
L-glutamate transmembrane transporter activity	IEA
high-affinity L-glutamate transmembrane transporter activity	TAS